Therese Lindvall
Lund University
7 Papers
54 Citations
Therese Lindvall is an academic researcher from Lund University. The author has contributed to research in topics: Arthritis & Locus (genetics). The author has an hindex of 6, co-authored 7 publications.
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Papers
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2
Annika Rogstam,Maria Nyblom,Signe Christensen,Céleste Sele,Vladimir O. Talibov,Therese Lindvall,Anna Rasmussen,Ingemar André,Zoë Fisher,Zoë Fisher,Wolfgang Knecht,Frank Kozielski +11 more
TL;DR: The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp 10 as a central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nSP10, interfering with crucial functions of the replication–transcription complex and virus replication.
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Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio.
Jenny C Karlsson,Martina Johannesson,Therese Lindvall,Patrik Wernhoff,Rikard Holmdahl,Åsa Andersson +5 more
TL;DR: Investigation of the CD4/CD8 T cell ratio in mice from the partially advanced intercross shows that this trait is linked to one of the Eae2 subloci through interactions with Eae3/Cia5.
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High resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice
Emma Ahlqvist,Diana Ekman,Therese Lindvall,Marjan Popovic,Marjan Popovic,Michael Förster,Michael Förster,Malin Hultqvist,Dorota Klaczkowska,Dorota Klaczkowska,Ivanka Teneva,Martina Johannesson,Martina Johannesson,Jonathan Flint,William Valdar,Kutty Selva Nandakumar,Kutty Selva Nandakumar,Rikard Holmdahl,Rikard Holmdahl +18 more
TL;DR: Using an inbred-outbred cross design, 26 loci, 18 of which are novel, controlling arthritis traits such as incidence of disease, severity and time of onset are identified and fine-mapped a number of previously mapped loci.
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Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice
Michael Förster,Bruno Raposo,Diana Ekman,Dorota Klaczkowska,Marjan Popovic,Kutty Selva Nandakumar,Therese Lindvall,Malin Hultqvist,Ivanka Teneva,Martina Johannesson,Emma Ahlqvist,Rikard Holmdahl +11 more
TL;DR: This comprehensive genetic analysis of autoantibody formation in CIA demonstrates an association not only of anti-CII, but interestingly also of ACPA and RF, with arthritis development in mice, underscoring the importance of non-major histocompatibility complex genes in controlling the formation of clinically relevant autoantsibodies.
Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes
TL;DR: The study shows the importance of breeding sub-congenic mouse strains to reveal genetic effects on complex diseases, and identifies a 3.2 mega base pair (Mbp) interval that regulates disease.