Theresa P. Pretlow
Case Western Reserve University
97 Papers
1.9K Citations
Theresa P. Pretlow is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Aberrant crypt foci & Prostate. The author has an hindex of 39, co-authored 97 publications. Previous affiliations of Theresa P. Pretlow include University of Alabama at Birmingham & University Hospitals of Cleveland.
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Papers
•Journal Article
Heterogeneity and subcompartmentalization in the distribution of eosinophils in human colonic carcinomas.
TL;DR: This is the first report that any kind of inflammatory cell is less concentrated in the periphery of a tumor than more centrally, and the concentrations of eosinophils at the margins were strikingly lower than the concentrations in the samples remote from the margins.
Altered Expression of RET Proto-oncogene Product in Prostatic Intraepithelial Neoplasia and Prostate Cancer
Dawn M. Dawson,Earl Lawrence,Gregory T. MacLennan,Saeid B. Amini,Hsing Jien Kung,Dan R. Robinson,Martin I. Resnick,Elroy D Kursh,Theresa P. Pretlow,Thomas G. Pretlow +9 more
TL;DR: expression of the RET proto-oncogene in benign prostatic epithelium, high-grade PIN, and histopathologically advanced prostate cancer suggests that RET may play a role in the growth of both benign and neoplastic prostate epithelial cells.
Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate.
TL;DR: The results validate the use of ACF with four or more crypts, as an intermediate biomarker for tumor incidence in this system, and are consistent with the hypothesis that the development of larger ACF (with four ormore crypts) is predictive of the tumor incidence.
•Journal Article
The identification of monoclonality in human aberrant crypt foci.
I. Mei Siu,Dan R. Robinson,Stuart Schwartz,Hsing Jien Kung,Thomas G. Pretlow,Robert B. Petersen,Theresa P. Pretlow +6 more
TL;DR: Results clearly demonstrate that a high percentage of Aberrant crypt foci lesions are neoplastic rather than hyperplastic; and ACF are the earliest identifiedNeoplastic lesions in the colon.