Thamara Beyer
University of Ulm
14 Papers
11 Citations
Thamara Beyer is an academic researcher from University of Ulm. The author has contributed to research in topics: Granzyme B & Interleukin 21. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Thamara Beyer include German Red Cross.
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Papers
Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
Stefanie Lindner,Karen Dahlke,Kai Sontheimer,Magdalena Hagn,Christof Kaltenmeier,Thomas F. E. Barth,Thamara Beyer,Frank Reister,Dorit Fabricius,Ramin Lotfi,Oleg Lunov,Gerd Ulrich Nienhaus,Thomas Simmet,Rolf Kreienberg,Peter Möller,Hubert Schrezenmeier,Bernd Jahrsdörfer +16 more
TL;DR: These findings establish the existence of human B cells with a regulatory phenotype in solid tumor infiltrates, where they may contribute to the suppression of antitumor immune responses and stimulate novel diagnostic and cell therapeutic approaches to better manage human cancer as well as autoimmune and graft-versus-host pathologies.
315
Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial
Jürgen Hetzel,Ralph Eberhardt,Fjf Herth,Christoph Petermann,G. Reichle,Lutz Freitag,I Dobbertin,Karl-Josef Franke,Franz Stanzel,Thamara Beyer,Peter Möller,P. Fritz,German Ott,Philipp A. Schnabel,H Kastendieck,W Lang,A. Morresi-Hauf,M Szyrach,Rainer Muche,Pallav L. Shah,A. Babiak,M Hetzel +21 more
TL;DR: Endobronchial cryobiopsy is a safe technique with superior diagnostic yield in comparison with conventional forceps biopsy and there was no difference in the incidence of significant bleeding.
267
Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help.
Magdalena Hagn,Kai Sontheimer,Karen Dahlke,Sabine Brueggemann,Christof Kaltenmeier,Thamara Beyer,S Hofmann,Oleg Lunov,Thomas F. E. Barth,Dorit Fabricius,Kyrylo Tron,Gerd Ulrich Nienhaus,Gerd Ulrich Nienhaus,Thomas Simmet,Hubert Schrezenmeier,Bernd Jahrsdörfer +15 more
TL;DR: It is shown that in the absence of CD40L, CD4+ T cell‐derived IL‐21 induces differentiation of B cells into granzyme B (GzmB)‐secreting cytotoxic cells, which may have a role in early cellular immune responses including tumor immunosurveillance before fully activated, antigen‐specific cytot toxic T cells are on the spot.
104
CD4+ T Cell–Derived IL-21 and Deprivation of CD40 Signaling Favor the In Vivo Development of Granzyme B–Expressing Regulatory B Cells in HIV Patients
Christof Kaltenmeier,Ali Gawanbacht,Thamara Beyer,Stefanie Lindner,Timo Trzaska,Johannes A. van der Merwe,Georg Härter,Beate Grüner,Dorit Fabricius,Ramin Lotfi,Klaus Schwarz,Catharina Schütz,Manfred Hönig,Ansgar Schulz,Peter Kern,Martin Bommer,Hubert Schrezenmeier,Frank Kirchhoff,Bernd Jahrsdörfer +18 more
TL;DR: GraB cells represent potent regulatory B cells in humans that are phenotypically and functionally distinct from B10 cells and occur in early HIV infection and may contribute significantly to immune dysfunction in HIV patients, and may also explain ineffective Ab responses after vaccination.
•Journal Article
Monocytes express the serine protease granzyme B - potential involvement in antigen processing and presentation. (P5033)
Christopher Schuldhaus,Thamara Beyer,Christof Kaltenmeier,Stefanie Lindner,Hubert Schrezenmeier,Bernd Jahrsdörfer +5 more
TL;DR: It is found that monocytes can express GrB depending on various external stimuli, and that the TLR4 ligand LPS appears to play a central role in the induction of GrB in monocytes, and the presence of antigen-stimulated B cells synergistically enhances GrB expression in monocyte.
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