Tetsuya Yabuuchi
Taisho Pharmaceutical Co.
10 Papers
66 Citations
Tetsuya Yabuuchi is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Hydroxamic acid & Transforming growth factor. The author has an hindex of 6, co-authored 10 publications.
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Papers
Patent
Novel hydroxamic acid derivative
Hajime Takashima,Risa Tsuruta,Tetsuya Yabuuchi,Yusuke Oka,Hiroki Urabe,Yoichiro Suga,Masato Takahashi,Fumito Uneuchi,Hironori Kotsubo,Muneo Shoji,Yasuko Kawaguchi +10 more
- 20 Apr 2011
TL;DR: In this article, a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria.
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Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
Yusuke Oka,Tetsuya Yabuuchi,Yasuyuki Fujii,Hidenori Ohtake,Shunichi Wakahara,Kayo Matsumoto,Mayumi Endo,Yunoshin Tamura,Yoshinori Sekiguchi +8 more
TL;DR: A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors and resulted in the identification of compounds 10 and 15, which displayed potent inhibitory activities in enzyme-based and cell-based assays.
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Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR.
Tetsuo Takayama,Hiroki Umemiya,Hideaki Amada,Tetsuya Yabuuchi,Fumiyasu Shiozawa,Hironori Katakai,Akiko Takaoka,Akie Yamaguchi,Mayumi Endo,Masakazu Sato +9 more
TL;DR: This work has described the synthesis, enzyme inhibitory activity, structure-activity relationships, and proposed binding mode of a novel series of pyrrole derivatives as lymphocyte-specific kinase (Lck) inhibitors as well as the most potent analogs.
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Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
Yusuke Oka,Tetsuya Yabuuchi,Takahiro Oi,Kuroda Shoichi,Yasuyuki Fujii,Hidenori Ohtake,Tomoyuki Inoue,Shunichi Wakahara,Kayo Kimura,Kiyoko Fujita,Mayumi Endo,Kyoko Taguchi,Yoshinori Sekiguchi +12 more
TL;DR: The synthesis and the structure-activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles are described, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
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Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR.
Tetsuo Takayama,Hiroki Umemiya,Hideaki Amada,Tetsuya Yabuuchi,Takeshi Koami,Fumiyasu Shiozawa,Yusuke Oka,Akiko Takaoka,Akie Yamaguchi,Mayumi Endo,Masakazu Sato +10 more
TL;DR: A novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors were identified and exhibited good enzyme inhibitory activity as well as excellent cellular activity against mixed lymphocyte reaction (MLR).
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