Tetsu Takeuchi
University of California, Los Angeles
10 Papers
143 Citations
Tetsu Takeuchi is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Intracellular pH & Gastric mucosa. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Tetsu Takeuchi include Keio University & Veterans Health Administration.
Chat about Author
Papers
Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.
Misa Mizumori,Justin G. Meyerowitz,Tetsu Takeuchi,Shu Lim,Paul W. N. Lee,Claudiu T. Supuran,Paul H. Guth,Eli Engel,Jonathan D. Kaunitz,Yasutada Akiba +9 more
TL;DR: In this article, Allen et al. showed that most of the excess duodenal luminal H+ was absorbed through neutralization of secreted HCO3−, yielding luminal CO2.
66
Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.
Yasutada Akiba,Sara Ghayouri,Tetsu Takeuchi,Misa Mizumori,Paul H. Guth,Eli Engel,Erik R. Swenson,Jonathan D. Kaunitz,Jonathan D. Kaunitz +8 more
TL;DR: The duodenal hyperemic response to luminal CO(2) is dependent on cytosolic and membrane-bound CA isoforms, NHE-1, and TRPV1, which suggests that luminalCO(2), which is sensed as H(+) in the subepithelium, is mediated by extracellular CA.
60
Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum
Masahiko Hirokawa,Masahiko Hirokawa,Tetsu Takeuchi,Tetsu Takeuchi,Sahaoyou Chu,Yasutada Akiba,Yasutada Akiba,Vincent Wu,Paul H. Guth,Eli Engel,Marshall H. Montrose,Jonathan D. Kaunitz,Jonathan D. Kaunitz +12 more
TL;DR: Increased cellular buffering power of the epithelial cells of DeltaF/DeltaF mice likely protects against acidification and injury during acid exposure, and it is speculated that this protective mechanism partially underlies the perceived relative lack of peptic ulceration in patients affected by cystic fibrosis.
36
Mechanism of augmented duodenal HCO3− secretion after elevation of luminal CO2
Osamu Furukawa,Masahiko Hirokawa,Lening Zhang,Tetsu Takeuchi,Luke C. Bi,Paul H. Guth,Eli Engel,Yasutada Akiba,Jonathan D. Kaunitz +8 more
TL;DR: Luminal CO(2) diffused in the duodenal epithelial cells and was converted to H(+) and HCO(3)(-) by carbonic anhydrase, which decreased epithelial cell pH(i), followed by an overshoot after removal of the CO( 2) solution.
26
Nuclear factor-κB and TNF-α mediate gastric ulceration induced by phorbol myristate acetate
Tetsu Takeuchi,Soichiro Miura,Lin Wang,Keita Uehara,Misa Mizumori,Hiroshi Kishikawa,Ryota Hokari,Hajime Higuchi,Masayuki Adachi,Hiromasa Nakamizo,Hiromasa Ishii +10 more
TL;DR: In this paper, the authors determined whether nuclear factor-kappaB and tumor necrosis factor-alpha (TNF-alpha) play role in the formation of gastric ulcer induced by phorbol-12-myristate-13-alphacetate (PMA) in rats.
17