https://doi.org/10.1016/j.bioactmat.2022.12.002

Smart dental materials for antimicrobial applications

Investigation through the anticancer properties of green synthesized spinel ferrite nanoparticles in present and absent of laser photothermal effect

Abstract In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer–emmett–teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S . aureus), Escherichia coli ( E . coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising. 

/pdf/an-intriguing-approach-toward-antibacterial-activity-of-fuf8wnej.pdf

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Exploring the potential of layered metal and metal oxide nanomaterials for sustainable water and wastewater treatment: A review of their antimicrobial properties.

Nowadays, nanoparticles such as gold nanoparticles (Au NPs) with specific biophysical characteristics have attracted remarkable attention as innovative options for the diagnosis and treatment of different diseases. In the present research, Au NPs were green synthesized using the Glaucium flavum leaf extract as an inexpensive and eco-friendly synthesis method. Then, the physicochemical properties were characterized by transmission electron microscopy (TEM), dynamic light scattering method (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet-visible absorption spectroscopy (UV-Vis), Zeta potential, and Fourier transform infrared (FTIR) spectroscopy. Afterwards, the antioxidant capacity was tested and antiviral activity against influenza virus was evaluated by applying TCID50 and PCR assays. The nanoparticles cytotoxicity was tested using the MTT method. The shape and size of Au nanoparticles were modulated by varying leaf concentrations with face-centered cubic (FCC) structure. At higher concentrations, long-time stable spherical nanoparticles were obtained with a mean particle size of 32 nm and low aggregation degree that could simply combine with various bioactive compounds. The outcomes exhibited effective antiviral and antioxidant activities with low cytotoxicity and acceptable biocompatibility of green synthesized Au NPs. The aim of the present study was to develop a potentially environmentally friendly nanoplatform with excellent antiviral and antioxidant functions and acceptable biocompatibility for promising biomedical applications in the future.The online version contains supplementary material available at 10.1007/s13204-022-02705-1. 

/pdf/antiviral-and-antioxidant-properties-of-green-synthesized-14on5xmk.pdf

Antiviral and antioxidant properties of green synthesized gold nanoparticles using Glaucium flavum leaf extract

Early detection of cancer is critical for providing safe and timely treatment to patients. To detect the existence of biological markers for cancer at very low levels in the early phases of tumor development, highly reliable and adaptable methods will be required. These methods have been proven to be effective in encouraging patients to create early intervention strategies, which may eventually contribute to an increase in the overall survival rate of the patient. As a result of nanotechnology, the development of nanometer-scale biosensors is possible, as is the provision of high sensitivity and adaptability. This allows for the identification of biochemical and biophysical signals associated with health hazards (transmittable or non-transmittable diseases such as cancer) at the level of individual molecules or cells. Designs like this stand out from the crowd because they offer unique properties such as strong electrical conductivity, increased shock-bearing capacity, and responsive responses such as piezoelectric and color changes in nanoparticle morphologies, which distinguish them from the competition. Aptamer-functionalized nanoparticles, due to their molecular architecture, have the potential to be used in a variety of new applications that go beyond their traditional role in biosensing. The use of gold nanostructures by cancer researchers has increased in recent years, owing to their ease of synthesis and surface mobility, their desirable and adjustable optical characteristics, and their good cytocompatibility in clinical settings, among other factors. As a result of the many characteristics that have resulted, these sensors have been extensively and successfully utilized in both optical and electrochemical applications. Investigations have been carried out on the effectiveness of gold nanoparticle-based biosensors that make use of aptamers as biosensor technology. It is the purpose of this study to review the advances made in the development of gold nanoparticle-based aptasensors, as well as their use in the discovery of cancer biomarkers for early-stage cancer diagnosis and subsequent therapy for the eradication of this deadly illness. 

Gold nanoparticle-based aptasensors: A promising perspective for early-stage detection of cancer biomarkers

Cancer overlooks are globally one of the most dangerous and life-threatening tribulations. While significant advances have been made in the targeted delivery of anti-cancer medications over the last few years, several challenges, such as low efficacy and strong toxic effects, remain to be addressed. Micro/nanomotors have been thoroughly studied for both effective cancer detection and treatment, as demonstrated by significant advancements in the architecture of smart and functional micro/nanomotor biomedical systems. Able to self-propelled within fluid media, micro/nanomotors have attractive vehicles to maximize the efficacy of tumor delivery. Here, we present the current developments in the delivery, detection, and imaging-guided treatment of micro/nanomotors in the clinical field, including cancer-related specific targeted drug delivery, and then discuss the barriers and difficulties encountered by micro/nanomotors throughout the medical process. Furthermore, this paper addresses the potential growth of micro/nanomotors for medical applications, and sets out the current drawbacks and future research directions for more advancement. 

Self-propelled micro/nanobots: A new insight into precisely targeting cancerous cells through intelligent and deep cancer penetration

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Gold nanoparticle-based aptasensors: A promising perspective for early-stage detection of cancer biomarkers

Self-propelled micro/nanobots: A new insight into precisely targeting cancerous cells through intelligent and deep cancer penetration