Teodor G. Păunescu
Harvard University
50 Papers
494 Citations
Teodor G. Păunescu is an academic researcher from Harvard University. The author has contributed to research in topics: Intercalated Cell & Apical membrane. The author has an hindex of 23, co-authored 47 publications. Previous affiliations of Teodor G. Păunescu include University of Illinois at Urbana–Champaign.
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Papers
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
Kevin C. Miranda,Daniel T. Bond,Mary McKee,Johan Skog,Teodor G. Păunescu,Nicolas Da Silva,Dennis Brown,Leileata M. Russo +7 more
TL;DR: This study isolated microvesicles from human urine and found them to have an RNA integrity profile similar to that of kidney tissue, including 18S and 28S rRNA, which was better preserved in urinarymicrovesicles compared with whole cells isolated from urine, suggesting that microvesicle may protect RNA during urine passage.
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Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Lihe Chen,Jae Wook Lee,Chung-Lin Chou,Anil V. Nair,Maria A. Battistone,Teodor G. Păunescu,Maria Merkulova,Sylvie Breton,Jill W. Verlander,Susan M. Wall,Dennis Brown,Maurice B. Burg,Mark A. Knepper +12 more
TL;DR: The identified patterns of gene expression among the three types of collecting duct cells provide a foundation for understanding physiological regulation and pathophysiology in the renal collecting duct.
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Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption.
TL;DR: It has been demonstrated that inhibition of phosphoinositide formation causes an inhibition of Na+ entry in both control and aldosterone-pretreated cultures by reducing the number of open functional epithelial Na+ channels (ENaCs) in the apical membrane of the A6 cells.
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Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation
Maria Merkulova,Teodor G. Păunescu,Anie Azroyan,Vladimir Marshansky,Sylvie Breton,Dennis Brown +5 more
TL;DR: In this paper, a proteomic analysis using kidney tissue revealed V-ATPase-associated protein clusters involved in protein quality control, complex assembly, and intracellular trafficking, and two interacting proteins, DMXL1 and WDR7, inhibited V-atpase-mediated intra-cell vesicle acidification in a kidney cell line.
V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.
R. Lance Miller,Ping Zhang,Maren Smith,Valérie Beaulieu,Teodor G. Păunescu,Dennis Brown,Sylvie Breton,Raoul D. Nelson +7 more
TL;DR: This EGFP-expressing mouse model should prove useful in future studies of gene and protein expression and their physiological and/or developmental regulation in distinct cell types that can now be separated using fluorescence-assisted microdissection, Fluorescence-activated cell sorting, and laser capture microdissections.
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