Tencho Tenev
Imperial College London
10 Papers
29 Citations
Tencho Tenev is an academic researcher from Imperial College London. The author has contributed to research in topics: Apoptosis & Transfection. The author has an hindex of 10, co-authored 10 publications. Previous affiliations of Tencho Tenev include The Breast Cancer Research Foundation.
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Papers
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
L. Miguel Martins,Ingram Iaccarino,Tencho Tenev,Stephen Gschmeissner,Nicholas F. Totty,Nicholas R. Lemoine,John Savopoulos,Carol W. Gray,Caretha L. Creasy,Colin Dingwall,Julian Downward +10 more
TL;DR: The serine protease Omi/HtrA2 is identified as a second mammalian XIAP-binding protein with a Reaper-like motif, and this protease autoprocesses to form a protein with amino-terminal homology to Smac/DIABLO and Reaper family proteins.
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The Developing Human Connectome Project: a Minimal Processing Pipeline for Neonatal Cortical Surface Reconstruction
Antonios Makropoulos,Emma C. Robinson,Emma C. Robinson,Andreas Schuh,Robert Wright,Sean P. Fitzgibbon,Jelena Bozek,Serena J. Counsell,Johannes K. Steinweg,Katy Vecchiato,Jonathan Passerat-Palmbach,Gregor Lenz,Filippo Mortari,Tencho Tenev,Eugene P. Duff,Matteo Bastiani,Lucilio Cordero-Grande,Emer Hughes,Nora Tusor,Jacques-Donald Tournier,Jana Hutter,Anthony N. Price,Rui Pedro A. G. Teixeira,Maria Murgasova,Suresh Victor,Christopher Kelly,Mary A. Rutherford,Stephen M. Smith,A. David Edwards,Joseph V. Hajnal,Mark Jenkinson,Daniel Rueckert +31 more
TL;DR: A fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain is proposed, which has been specifically designed to address considerable differences between adult and neonatal brains, as imaged using MRI.
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Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis
TL;DR: The identified and characterized novel splice variants of human Bim mRNA show that a newly discovered, small protein isoform, BimAD, is also able to induce apoptosis strongly in several human cell lines, indicating that Bim can regulate apoptosis through direct activation of the Bax-mediated cell death pathway without interaction with antiapoptotic Bcl-2 family members.
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The Developing Human Connectome Project: a Minimal Processing Pipeline for Neonatal Cortical Surface Reconstruction
Antonios Makropoulos,Emma C. Robinson,Andreas Schuh,Robert Wright,Sean P. Fitzgibbon,Jelena Bozek,Serena J. Counsell,Johannes K. Steinweg,Jonathan Passerat-Palmbach,Gregor Lenz,Filippo Mortari,Tencho Tenev,Eugene P. Duff,Matteo Bastiani,Lucilio Cordero-Grande,Emer Hughes,Nora Tusor,Jacques-Donald Tournier,Jana Hutter,Anthony N. Price,Maria Murgasova,Christopher Kelly,Mary A. Rutherford,Stephen M. Smith,A. David Edwards,Joseph V. Hajnal,Mark Jenkinson,Daniel Rueckert +27 more
TL;DR: Results demonstrate that images collected from 465 subjects ranging from 28 to 45 weeks post-menstrual age (PMA) can be fully automatically processed; generating cortical surface models that are topologically and anatomically correct.
Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.
TL;DR: It is demonstrated that pro-caspase-3 can sensitise ovarian cancer cells to proteasome inhibitor-induced apoptosis, and a combination of these approaches might be exploited for therapy of ovarian and other cancers.
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