Tej B. Shrestha
Kansas State University
53 Papers
346 Citations
Tej B. Shrestha is an academic researcher from Kansas State University. The author has contributed to research in topics: Drug delivery & Medicine. The author has an hindex of 18, co-authored 46 publications. Previous affiliations of Tej B. Shrestha include Florida State University College of Arts and Sciences.
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Papers
Copper resistance is essential for virulence of Mycobacterium tuberculosis
Frank Wolschendorf,David F. Ackart,Tej B. Shrestha,Laurel Hascall-Dove,Scott Nolan,Gyanu Lamichhane,Ying Wang,Stefan H. Bossmann,Randall J. Basaraba,Michael Niederweis +9 more
TL;DR: Evidence is provided that Cu is used by the mammalian host to control Mtb infection and that Cu resistance mechanisms are crucial for Mtb virulence, revealing an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy.
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Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release.
TL;DR: An improved liposome system that can target more specifically, with faster release kinetics and lower general leaking, is created by deliberately producing a very unstableliposome that is subsequently stabilized by a cross-linked polymer shell containing consensus sequences for cancer-associated proteases (protease-triggered, caged liposomes).
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Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus
Mehri Haeili,Casey Moore,Christopher J. C. Davis,James B. Cochran,Santosh Shah,Tej B. Shrestha,Yaofang Zhang,Stefan H. Bossmann,William H. Benjamin,Olaf Kutsch,Frank Wolschendorf +10 more
TL;DR: A novel high-throughput screening platform specifically developed for the discovery and characterization of compounds with copper-dependent antibacterial properties toward methicillin-resistant Staphylococcus aureus and how one of the identified compounds, glyoxal-bis(N4-methylthiosemicarbazone) (GTSM), exerts its potent strictly copper- dependence on MRSA is reported.
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Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells
Lei Wang,Ziyan Liu,Sivasai Balivada,Tej B. Shrestha,Stefan H. Bossmann,Marla Pyle,Loretta Pappan,Jishu Shi,Deryl L. Troyer +8 more
TL;DR: This finding indicates thatglioma cells without self-renewal capability in standard conditions could also contribute to glioma malignancy when cytokines, such as IL-1β and TGF-β, are present in the tumor environment.
Magnetic-Fe/Fe(3)O(4)-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages
Hongwang Wang,Tej B. Shrestha,Matthew T. Basel,Raj Kumar Dani,Gwi-Moon Seo,Sivasai Balivada,Marla Pyle,Heidy Prock,Olga Koper,Prem S. Thapa,David S. Moore,Ping Li,Viktor Chikan,Deryl L. Troyer,Stefan H. Bossmann +14 more
TL;DR: The synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe3O4 magnetic nanoparticles (MNPs) and the topoisomerase I blocker SN38 bound to the surface of the MNPs via a carboxylesterase cleavable linker, which demonstrated high heating ability in an AC-magnetic field.
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