Tathagata Chakraborty
Chittaranjan National Cancer Institute
12 Papers
38 Citations
Tathagata Chakraborty is an academic researcher from Chittaranjan National Cancer Institute. The author has contributed to research in topics: Immune system & Downregulation and upregulation. The author has an hindex of 10, co-authored 12 publications.
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Papers
•Journal Article
Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients
TL;DR: Assessment of the extent of immune dysfunction might help design immunotherapeutic protocols by incorporating any agent having immunomodulatory function and Dysregulation in the profile of immunocompetent cells and cytokine secretion was reflected in the suppressed cytotoxic function of HNSCC PBMCs.
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Neem Leaf Glycoprotein Induces Perforin-mediated Tumor Cell Killing by T and NK Cells Through Differential Regulation of IFNγ Signaling
Anamika Bose,Krishnendu Chakraborty,Koustav Sarkar,Shyamal Goswami,Tathagata Chakraborty,Smarajit Pal,Rathindranath Baral +6 more
TL;DR: It is concluded that NLGP might be effective to recover the suppressed cytotoxic functions of NK and T cells from head and neck squamous cell carcinoma patients.
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Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity
Krishnendu Chakraborty,Anamika Bose,Tathagata Chakraborty,Koustav Sarkar,Shyamal Goswami,Smarajit Pal,Rathindranath Baral +6 more
TL;DR: Neem leaf glycoprotein (NLGP), a novel immunomodulator reported from the laboratory, is used to restore CCR5 receptor–ligand signaling in monocyte/macrophage surfaces in head and neck squamous cell carcinoma patients and suggest a new approach in cancer immunotherapy by modulating dysregulated CCR 5 signals from MO/Mφ.
Neem leaf glycoprotein inhibits CD4+CD25+Foxp3+ Tregs to restrict murine tumor growth.
Tathagata Chakraborty,Anamika Bose,Subhasis Barik,Kuntal Kanti Goswami,Saptak Banerjee,Shyamal Goswami,Diptendu Ghosh,Soumyabrata Roy,Krishnendu Chakraborty,Koustav Sarkar,Rathindranath Baral +10 more
TL;DR: The possibility of NLGP being an excellent tool as a T-cell anergy breaker by abrogating the suppressor functions of Tregs in cancer needs to be explored further in the clinic.
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Neem leaf glycoprotein suppresses regulatory T cell mediated suppression of monocyte/macrophage functions.
Tathagata Chakraborty,Anamika Bose,Kuntal Kanti Goswami,Shyamal Goswami,Krishnendu Chakraborty,Rathindranath Baral +5 more
TL;DR: Results suggest that Treg influenced pro-tumor MO/Mφ functions are rectified in a significant extent by NLGP to create an anti-Tumor immune environment.
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