Tarrant Cummins
Monash University
9 Papers
Tarrant Cummins is an academic researcher from Monash University. The author has contributed to research in topics: Genome-wide association study & Attention deficit hyperactivity disorder. The author has an hindex of 7, co-authored 9 publications.
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Papers
The molecular genetic architecture of attention deficit hyperactivity disorder
Ziarih Hawi,Tarrant Cummins,Janette Tong,Beth Patricia Johnson,Ricky Wai Kiu Lau,W Samarrai,Mark A. Bellgrove +6 more
TL;DR: A state-of-the-art review of the molecular genetics of ADHD incorporating evidence from candidate gene and linkage designs, as well as genome-wide association studies of common single-nucleotide polymorphisms (SNPs) and rare copy number variations (CNVs).
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Identification and functional characterisation of a novel dopamine beta hydroxylase gene variant associated with attention deficit hyperactivity disorder.
Janette Tong,Leigh-Anne McKinley,Tarrant Cummins,Beth Patricia Johnson,Natasha Matthews,Alasdair Vance,Helen Heussler,Michael Gill,Lindsey Kent,Mark A. Bellgrove,Ziarih Hawi +10 more
TL;DR: Data demonstrate for the first time that a DBH gene variant, rs129882, which confers risk to ADHD is also associated with reduced in vitro gene expression, consistent with a relative hypo-noradrenergic state in ADHD.
Separating the wheat from the chaff: systematic identification of functionally relevant noncoding variants in ADHD.
Janette Tong,Ziarih Hawi,Callum Dark,Tarrant Cummins,Beth Patricia Johnson,Daniel P. Newman,Ricky Wai Kiu Lau,Alasdair Vance,Helen Heussler,Natasha Matthews,Mark A. Bellgrove,Ken C Pang +11 more
TL;DR: This study defines a set of 2070 DNA variants that showed evidence of association with ADHD, and proposes that these 65 variants, which possess not only a high likelihood of pathogenicity but also readily testable functional hypotheses, represent a tractable shortlist for future experimental validation in ADHD.
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Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection.
Daniel P. Newman,Tarrant Cummins,Janette Tong,Beth Patricia Johnson,Hayley Pickering,Peter Fanning,Joseph Wagner,Jack T T Goodrich,Ziarih Hawi,Christopher D. Chambers,Mark A. Bellgrove +10 more
TL;DR: A cognitive genetic approach was taken to adjudicate between roles for dopamine in attentional versus response selection, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.
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Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11).
Jasmine B. Taylor,Tarrant Cummins,Allison M. Fox,Beth Patricia Johnson,Janette Tong,Troy A. W. Visser,Ziarih Hawi,Mark A. Bellgrove +7 more
TL;DR: Findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses, as measured by the BIS-11.
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