Tao Wang
Tsinghua University
71 Papers
351 Citations
Tao Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Medicine & Visual phototransduction. The author has an hindex of 23, co-authored 56 publications. Previous affiliations of Tao Wang include ShanghaiTech University & Johns Hopkins University School of Medicine.
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Papers
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
Liming Yan,Ji Ge,Litao Zheng,Ying Zhang,Yan Gao,Tao Wang,Yucen Huang,Yunxiang Yang,Shan Gao,Mingyu Li,Zhenyu Liu,Haofeng Wang,Yingjian Li,Yu Chen,Luke W. Guddat,Quan Wang,Zihe Rao,Zihe Rao,Zhiyong Lou +18 more
TL;DR: A structural snapshot of SARS-CoV-2 RTC as it transition towards cap structure synthesis is presented, paving a way to understand the RTC architecture, and providing a target for antiviral development.
269
Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome
Cheng Ran Lisa Huang,Anna M. Schneider,Yunqi Lu,Tejasvi Niranjan,Peilin Shen,Matoya A. Robinson,Jared P. Steranka,David Valle,Curt I. Civin,Tao Wang,Sarah J. Wheelan,Sarah J. Wheelan,Hongkai Ji,Jef D. Boeke,Kathleen H. Burns +14 more
TL;DR: The data suggest that the occurrence of new insertions is twice as high as previously estimated, and that these repeats are under-recognized as sources of human genomic and phenotypic diversity.
263
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease
Tao Wang,Uyen Lao,Bruce A. Edgar +2 more
TL;DR: It is found that genetically inhibiting TOR or inducing autophagy suppresses cell death in Drosophila models of Huntington's disease and phospholipase C (norpA)-mediated retinal degeneration and provides direct genetic evidence that Autophagy alleviates celldeath in several common types of neurodegenerative disease.
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Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
Liming Yan,Liming Yan,Yunxiang Yang,Mingyu Li,Ying Zhang,Litao Zheng,Litao Zheng,Ji Ge,Yucen C. Huang,Zhenyu Liu,Tao Wang,Tao Wang,Shan Gao,Ran Zhang,Yuanyun Y. Huang,Luke W. Guddat,Yan Gao,Zihe Rao,Zhiyong Lou +18 more
TL;DR: In this paper, the structure of the SARS-CoV-2 replication-transcription complex (RTC) in a form identified as Cap(0)-RTC, which couples a cotranscriptional capping complex (CCC) composed of nsp12 NiRAN, nsp9, the bifunctional nsp14 possessing an N-terminal exoribonuclease (ExoN) and a Cterminal N7-methyltransferase (N7-MTase), and nsp10 as a cofactor of n
134
Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
TL;DR: A class B scavenger receptor is identified that functions upstream of vitamin A formation in neurons and glia, which are outside of the retina, and a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin is proposed.
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