18 Papers
160 Citations
Tao Du is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Fusion protein & Immune system. The author has an hindex of 10, co-authored 18 publications.
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Papers
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.
Chang Li,Xinmeng Guan,Tao Du,Wei Jin,Biao Wu,Yalan Liu,Ping Wang,Bodan Hu,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +11 more
TL;DR: It is demonstrated that CRISPR/Cas9 can efficiently mediate the editing of the C CR5 locus in cell lines, resulting in the knockout of CCR5 expression on the cell surface, and this is the first study establishing HIV-1 resistance in primary CD4(+) T-cells utilizing adenovirus-delivered CRISpr/ Cas9.
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Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction.
Xin Huang,Wei Jin,Kai Hu,Sukun Luo,Tao Du,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +8 more
TL;DR: This study demonstrates for the first time that removal of individual glycan N156, N262 or N410 proximal to CD4-binding region impairs viral infectivity and results in enhanced capability to induce neutralizing activity.
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DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein
Ping Wang,Kai Hu,Sukun Luo,Mudan Zhang,Xu Deng,Chang Li,Wei Jin,Bodan Hu,Siyi He,Mei Li,Tao Du,Gengfu Xiao,Bo Zhang,Yalan Liu,Qinxue Hu,Qinxue Hu +15 more
TL;DR: The high-mannose N-linked glycan at N154 of E glycoprotein was shown to be crucial for JEV binding to DC-SIGN and subsequent internalization, while mutation of DC-sign internalization motif did not affect JEV uptake and internalization and suggest that DC- SIGN functions as an attachment factor rather than an entry receptor for J EV.
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CCL19 and CCL28 Augment Mucosal and Systemic Immune Responses to HIV-1 gp140 by Mobilizing Responsive Immunocytes into Secondary Lymph Nodes and Mucosal Tissue
Kai Hu,Sukun Luo,Lina Tong,Xin Huang,Wei Jin,Wenjie Huang,Tao Du,Yan Yan,Siyi He,George E. Griffin,Robin J. Shattock,Qinxue Hu,Qinxue Hu +12 more
TL;DR: PCCL19 and pCCL28 can enhance HIV-1 envelope–specific systemic and mucosal Ab responses, as well as T cell responses, and such enhancements appear to be associated with mobilization of responsive immunocytes into secondary lymphoid organs and mucosa tissues through interactions with corresponding receptors.
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HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter
Mudan Zhang,Yalan Liu,Ping Wang,Xinmeng Guan,Siyi He,Sukun Luo,Chang Li,Kai Hu,Wei Jin,Tao Du,Yan Yan,Zhenfeng Zhang,Zhenhua Zheng,Hanzhong Wang,Qinxue Hu,Qinxue Hu +15 more
TL;DR: It is demonstrated that productive HSV-2 infection suppresses Sendai virus (SeV) or polyinosinic-polycytidylic acid-induced IFN-β production, and it is revealed that US1, an immediate-early protein of HSv-2, contributes to such suppression, demonstrating an unconventional strategy exploited by a dsDNA virus to interrupt type I IFN signaling pathway.
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