Tanweer A. Khan
Merck & Co.
28 Papers
161 Citations
Tanweer A. Khan is an academic researcher from Merck & Co.. The author has contributed to research in topics: Hypophosphite & Electron donor. The author has an hindex of 12, co-authored 27 publications. Previous affiliations of Tanweer A. Khan include Schering-Plough & University of Strathclyde.
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Papers
Highly Efficient Reduction of Unactivated Aryl and Alkyl Iodides by a Ground‐State Neutral Organic Electron Donor
TL;DR: In this article, the electron transfer reduction of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule is described, and the reducing agent is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products.
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Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle
Paola Favuzza,Paola Favuzza,Manuel de Lera Ruiz,Jennifer K. Thompson,Tony Triglia,Anna Ngo,Ryan W.J. Steel,Ryan W.J. Steel,Marissa Vavrek,Janni Christensen,Janni Christensen,Julie Healer,Julie Healer,Christopher W. Boyce,Zhuyan Guo,Mengwei Hu,Tanweer A. Khan,Nicholas Murgolo,Lianyun Zhao,Jocelyn Sietsma Penington,Kitsanapong Reaksudsan,Kitsanapong Reaksudsan,Kate E. Jarman,Melanie H. Dietrich,Melanie H. Dietrich,Lachlan Richardson,Lachlan Richardson,Kai-Yuan Guo,Kai-Yuan Guo,Sash Lopaticki,Wai-Hong Tham,Wai-Hong Tham,Matthias Rottmann,Tony Papenfuss,Tony Papenfuss,Jonathan A. Robbins,Justin A Boddey,Justin A Boddey,Brad E. Sleebs,Brad E. Sleebs,Helene Jousset Sabroux,Helene Jousset Sabroux,John A. Mccauley,David B. Olsen,Alan F. Cowman,Alan F. Cowman +45 more
TL;DR: It is demonstrated that PMX is a master modulator of merozoite invasion and direct maturation of proteins required for invasion, parasite development, and egress and dual inhibitors of PMIX and PMX that block multiple stages of the Plasmodium life cycle are described.
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Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor
Tanweer A. Khan,John A. Murphy +1 more
- 26 Mar 2006
TL;DR: The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products
117
Diethylphosphine oxide (DEPO): high-yielding and facile preparation of indolones in water
TL;DR: The process proceeds at a much lower temperature than is required for efficient reaction with toxic tributyltin hydride in benzene and permits significantly higher isolated yields than the corresponding reaction mediated by ethylpiperidine hypophosphite (EPHP).
83
Novel phosphorus radical-based routes to horsfiline.
TL;DR: In particular, DEPO is useful for effecting cyclizations at 80 degrees C that are difficult or impossible with Bu(3)SnH as mentioned in this paper, and it is used in two related approaches to synthesis of the alkaloid horsfiline.
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