Tang Hai
Chinese Academy of Sciences
46 Papers
114 Citations
Tang Hai is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 18, co-authored 40 publications. Previous affiliations of Tang Hai include China Agricultural University.
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Papers
iPS cells produce viable mice through tetraploid complementation
Xiaoyang Zhao,Wei Li,Zhuo Lv,Lei Liu,Man Tong,Tang Hai,Jie Hao,Chang-long Guo,Qingwen Ma,Liu Wang,Fanyi Zeng,Qi Zhou +11 more
TL;DR: The generation of several iPS cell lines that are capable of generating viable, fertile live-born progeny by tetraploid complementation and confirm that iPS cells can attain true pluripotency that is similar to that of ES cells.
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One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system
Xianlong Wang,Chunwei Cao,Jiaojiao Huang,Jing Yao,Tang Hai,Qiantao Zheng,Xiao Wang,Hongyong Zhang,Guosong Qin,Jinbo Cheng,Yanfang Wang,Zengqiang Yuan,Qi Zhou,Hongmei Wang,Jianguo Zhao +14 more
TL;DR: The results demonstrate that the simplicity, efficiency, and power of the CRISPR/Cas9 system to allow for the modification of multiple genes in pigs and yield results of high medical value.
Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs.
Guanghai Xiang,Jilong Ren,Tang Hai,Rui Fu,Dawei Yu,Jing Wang,Jing Wang,Wei Li,Haoyi Wang,Qi Zhou +9 more
TL;DR: Results indicated that editing IGF2 intron 3–3072 site using CRISPR–Cas9 technology improved meat production in Bama pigs, the first demonstration that editing non-coding region can improve economic traits in livestock.
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Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs
Xianlong Wang,Jinwei Zhou,Chunwei Cao,Jiaojiao Huang,Tang Hai,Yanfang Wang,Qiantao Zheng,Hongyong Zhang,Guosong Qin,Xiangnan Miao,Hongmei Wang,Cao Suizhong,Qi Zhou,Jianguo Zhao +13 more
TL;DR: A single blastocyst genotyping system is described to provide a simple and rapid solution to evaluate and compare the sgRNA efficiency at inducing indel mutations for a given gene locus and considerably reduces the uncertainties and expands the practical possibilities of CRISPR/Cas9-mediated genome engineering in pigs.
Generation and characterization of stable pig pregastrulation epiblast stem cell lines.
Minglei Zhi,Jinying Zhang,Qianzi Tang,Dawei Yu,Shuai Gao,Dengfeng Gao,Pengliang Liu,Jianxiong Guo,Tang Hai,Jie Gao,Suying Cao,Zimo Zhao,Chongyang Li,Xiaogang Weng,Mengnan He,Tianzhi Chen,Yingjie Wang,Keren Long,Deling Jiao,Guanglei Li,Jiaman Zhang,Yan Liu,Yu Lin,Daxin Pang,Qianqian Zhu,Naixin Chen,Jingjing Huang,Xinze Chen,Yixuan Yao,Jingcang Yang,Zicong Xie,Xianya Huang,Mengxin Liu,Ran Zhang,Qiuyan Li,Yiliang Miao,Jianhui Tian,Xingxu Huang,Hongsheng Ouyang,Bofeng Liu,Wei Xie,Qi Zhou,Hong-Jiang Wei,Zhonghua Liu,Caihong Zheng,Mingzhou Li,Jianyong Han +46 more
TL;DR: In this article, a large-scale single-cell transcriptome analysis of pig embryos from embryonic day (E) 0 to E14, specifically, the tracing of pluripotency changes during epiblast development, was performed.
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