7 Papers
3 Citations
Tan Tan is an academic researcher from China Agricultural University. The author has contributed to research in topics: Biology & Internal medicine. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Tan Tan include Ministry of Agriculture and Rural Development.
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Papers
Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163.
Chen Jingyao,Haitao Wang,Jianhui Bai,Wenjie Liu,Xiaojuan Liu,Dawei Yu,Tao Feng,Sun Zhaolin,Linlin Zhang,Linyuan Ma,Yiqing Hu,Yunlong Zou,Tan Tan,Jie Zhong,Man Hu,Xiaofei Bai,Dengke Pan,Yiming Xing,Yaofeng Zhao,Kegong Tian,Kegong Tian,Xiaoxiang Hu,Ning Li +22 more
TL;DR: Modifying CD163 remarkably inhibited PRRSV replication and protected pigs from HP-PRRSV infection, thus establishing a good foundation for breeding PR RSV-resistant pigs via gene editing technology.
Leptin mediates the effects of melatonin on female reproduction in mammals
Dongying Lv,Tan Tan,Tianqi Zhu,Jing Wang,Suhong Zhang,Lu Zhang,Xiaoxiang Hu,Guoshi Liu,Yiming Xing +8 more
TL;DR: It was observed that melatonin positively regulated the level of leptin in female mouse and pig and helped to understand the potential association between melatonin and leptin on the female reproductive activities.
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Screen and Verification for Transgene Integration Sites in Pigs
Linyuan Ma,Yuzhe Wang,Haitao Wang,Yiqing Hu,Chen Jingyao,Tan Tan,Man Hu,Xiaojuan Liu,Ran Zhang,Yiming Xing,Yiqiang Zhao,Xiaoxiang Hu,Ning Li +12 more
TL;DR: It is anticipated that Pifs501 will have useful applications in pig genome engineering, though the identification of genomic safe harbor should over long-term various functional studies be identified.
Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis
Tan Tan,Zhiyuan Song,Wenya Li,Runming Wang,Mingli Zhu,Zuoxiang Liang,Yilina Bai,Qi Wang,Hanyu Wu,Xiaoxiang Hu,Yiming Xing +10 more
TL;DR: The Leptin-deficient pigs presents an ideal model to illustrate the full spectrum of human NAFLD and the activity of AMPK signaling pathway suggests a potential target to develop new strategy for the diagnosis and treatment ofNAFLD.
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The effects of intrinsic apoptosis on cystogenesis in PKD1-deficient ADPKD pig model.
TL;DR: In this article, the authors investigated the role of intrinsic apoptosis in kidney cystogenesis in PKD1-deficient pigs and showed that intrinsic and extrinsic apoptosis played important roles in the development of kidney epithelial cells.
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