Tamotsu Yoshimori
Osaka University
275 Papers
1.4K Citations
Tamotsu Yoshimori is an academic researcher from Osaka University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 97, co-authored 250 publications. Previous affiliations of Tamotsu Yoshimori include National Institute for Basic Biology, Japan & Wayne State University.
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Papers
Mediatory molecules that fuse autophagosomes and lysosomes.
TL;DR: VAMP8 and Vti1b mediate fusion with lysosomes in both antimicrobial and canonical autophagy, indicating that xenophagy is functionally impaired.
Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy
Naoko Taguchi-Atarashi,Maho Hamasaki,Kohichi Matsunaga,Hiroko Omori,Nicholas T. Ktistakis,Tamotsu Yoshimori,Takeshi Noda +6 more
TL;DR: Results indicate that autophagy initiation depends on the balance between PI 3‐kinase and PI 3-phosphatase activity, and local levels of PtdIns3P at the site of autophagosome formation determine autophile initiation and the size of the autophagic membrane structure.
Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain
TL;DR: Rubicon, a subunit of the Beclin 1-PI3-kinase complex and its homologue, PLEKHM1, negatively regulate endocytic pathway through the interaction with Rab7.
Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome
TL;DR: A novel role of phosphoinositide on lysosomes and an association between autophagy and neuronal disease are revealed and reveal the mechanisms underlying autophagosome–lysosome fusion process.
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
Tadashi Yamamuro,Shuhei Nakamura,Yu Yamano,Tsutomu Endo,Kyosuke Yanagawa,Ayaka Tokumura,Takafumi Matsumura,Kiyonori Kobayashi,Hideto Mori,Yusuke Enokidani,Gota Yoshida,Hitomi Imoto,Tsuyoshi Kawabata,Tsuyoshi Kawabata,Maho Hamasaki,Akiko Kuma,Sohei Kuribayashi,Kentaro Takezawa,Yuki Okada,Manabu Ozawa,Shinichiro Fukuhara,Takashi Shinohara,Masahito Ikawa,Masahito Ikawa,Tamotsu Yoshimori +24 more
TL;DR: The authors found that systemic knockout mice of Rubicon, a negative regulator of autophagy, exhibited a substantial reduction in testicular weight, spermatogenesis, and male fertility, associated with upregulation of autoophagy.