Tamotsu Yoshimori
Osaka University
275 Papers
1.4K Citations
Tamotsu Yoshimori is an academic researcher from Osaka University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 97, co-authored 250 publications. Previous affiliations of Tamotsu Yoshimori include National Institute for Basic Biology, Japan & Wayne State University.
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Papers
Autophagy-independent function of lipidated LC3 essential for TFEB activation during the lysosomal damage responses
TL;DR: This study found that a master transcription factor regulating autophagy and lysosomal biogenesis, TFEB (transcription factor EB) is activated during lysOSomal damage, and this activation depends on an Autophagy-independent function of lipidated LC3, which localizes on lyssomes.
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Regulation of dsDNA-induced innate immune responses by membrane trafficking.
TL;DR: Findings indicate that dynamic membrane trafficking is triggered by dsDNA stimulation and plays a pivotal role in the signal transduction required for optimal activation of the innate immune response.
23
Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid.
Mitsuo Tagaya,Nobuhiro Henomatsu,Tamotsu Yoshimori,Akitsugu Yamamoto,Yutaka Tashiro,Shoji Mizushima +5 more
TL;DR: Although NDGA had an inhibitory effect on protein synthesis, it induced the expression of BiP, a chaperone located in the endoplasmic reticulum, a consequence of the inhibition of protein transport by NDGA.
23
Intracellular fate of Ureaplasma parvum entrapped by host cellular autophagy.
Fumiko Nishiumi,Michinaga Ogawa,Yukiko Nakura,Yusuke Hamada,Masahiro Nakayama,Jiro Mitobe,Atsushi Hiraide,Norio Sakai,Makoto Takeuchi,Tamotsu Yoshimori,Itaru Yanagihara +10 more
- 15 Jan 2017
TL;DR: This research has successfully shown that Ureaplasma spp.
23
Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion.
TL;DR: The identification of a novel regulator of autophagy, INPP5E (inositol polyphosphate-5-phosphatase E), which is essential for autophagosome-lysosome fusion and results indicate that defects in Autophagy play a critical role in pathogenesis.
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