Tamotsu Yoshimori
Osaka University
275 Papers
1.4K Citations
Tamotsu Yoshimori is an academic researcher from Osaka University. The author has contributed to research in topics: Autophagy & Biology. The author has an hindex of 97, co-authored 250 publications. Previous affiliations of Tamotsu Yoshimori include National Institute for Basic Biology, Japan & Wayne State University.
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Papers
Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Differentiation.
Daiki Murase,Ayumi Kusaka-Kikushima,Akira Hachiya,Rachel Fullenkamp,Anita Stepp,Asuka Imai,Mizuki Ueno,Keigo Kawabata,Yoshito Takahashi,Tadashi Hase,Atsushi Ohuchi,Shuhei Nakamura,Tamotsu Yoshimori +12 more
TL;DR: The present results indicate that the restoration of autophagy can contribute to improving premature skin aging by various intrinsic and extrinsic factors via the normalization of protein homeostasis.
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•Journal Article
Inhibition of intracellular transport of newly synthesized prolactin by bafilomycin A1 in a pituitary tumor cell line, GH3 cells
TL;DR: Investigation of the effects of bafilomycin A1 on the secretion and intracellular distribution of prolactin in cultured rat pituitary tumor cells suggests that acidification in immature secretory granules generated by a vacuolar type H(+)-ATPase is necessary for the intrACEllular transport of prol actin, maturation and concentration processes of the secretorygranules.
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Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4
Yuki Ohsaki,Yuko Sugimoto,Michitaka Suzuki,Hiroshi Hosokawa,Tamotsu Yoshimori,Joanna P. Davies,Yiannis A. Ioannou,Marie T. Vanier,Kousaku Ohno,Haruaki Ninomiya +9 more
TL;DR: The results suggest that ubiquitylation of NPC1 and its association with the ESCRT complex are controlled by endosomal cholesterol levels utilizing a mechanism that involves NPC2.
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Atg4B(C74A) hampers autophagosome closure: a useful protein for inhibiting autophagy.
TL;DR: The ability of the excess Atg4B mutant to inhibit autophagy provides not only an opportunity for further analysis of the LC3 system but also a useful tool available for a wide variety of experimental systems used in the study of autophagic degradation.
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Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B
Michio Inoue,Hironari Kamikubo,Mikio Kataoka,Ryuichi Kato,Ryuichi Kato,Tamotsu Yoshimori,Soichi Wakatsuki,Soichi Wakatsuki,Masato Kawasaki,Masato Kawasaki +9 more
TL;DR: Gel filtration and small‐angle X‐ray scattering experiments showed that the ATP‐bound form of SKD1 oligomerizes in solution, whereas ADP‐bound and apo forms ofSKD1 exist as monomers, even though the conformations of theADP‐ and ATP‐ bound forms are nearly identical.
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