Tamio Hayashi
Nanyang Technological University
806 Papers
8K Citations
Tamio Hayashi is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 98, co-authored 799 publications. Previous affiliations of Tamio Hayashi include South University & Hanyang University.
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Papers
Asymmetric Synthesis of 2-Aryl-2,3-dihydro-4-quinolones by Rhodium-Catalyzed 1,4-Addition of Arylzinc Reagents in the Presence of Chlorotrimethylsilane.
TL;DR: Rhodium-catalyzed 1,4-addition of arylzinc reagents to 4-quinolones yields 2-aryl-2,3-dihydro-4-quinolones with high enantioselectivity and yields, facilitated by (R)-binap ligand and chlorotrimethylsilane.
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Palladium-catalyzed synthesis of 4-oxaspiro[2.4]heptanes via central attack of oxygen nucleophiles to π-allylpalladium intermediates.
TL;DR: A palladium-catalyzed decarboxylative cyclopropanation of γ-methylidene-δ-valerolactones with aromatic aldehydes with aromaticaldehyde has been developed to give 4-oxaspiro[2.4]heptanes with high selectivity.
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Asymmetric Synthesis Catalyzed by Chiral Ferrocenylphosphine-Transition Metal Complexes
TL;DR: An X-ray diffraction study of PdCl 2 (BPPFA) was carried out in this paper, where the authors showed that the orientation of the four phenyl groups around the phosphorus atoms is nearly the same as that in its achiral analogue, DPPF (dppf = 1,1′-bis(diphenylphosphino)ferrocene).
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Palladium-Catalyzed Asymmetric Reduction of Racemic Allylic Esters with Formic Acid: Effects of Phosphine Ligands on Isomerization of π-Allylpalladium Intermediates and Enantioselectivity
TL;DR: In this article, a new MOP ligand (1b ), (R )-(+)-2-(bis(3-trifluoromethylphenyl)phosphino)-2′-methoxy-1,1′-binaphthyl, was found to be more enantioselective than other mOP ligands for the palladium-catalyzed asymmetric reduction of α,α-disubstituted allylic esters with formic acid.
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Highly enantioselective 1,4-addition of arylzinc reagents to 3-arylpropenals catalyzed by a rhodium–binap complex in the presence of chlorotrimethylsilane
Norihito Tokunaga,Tamio Hayashi +1 more
TL;DR: Asymmetric 1,4-addition of arylzinc chlorides to (E)-3-arylpropenals with high enantioselectivity in the presence of a rhodium/(R)-binap catalyst and chlorotrimethylsilane is described in this paper.
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