Tamara Kögl
University of Freiburg
8 Papers
10 Citations
Tamara Kögl is an academic researcher from University of Freiburg. The author has contributed to research in topics: Hemophagocytic lymphohistiocytosis & Cytotoxic T cell. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Tamara Kögl include University Medical Center Freiburg.
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Papers
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Birthe Jessen,Sebastian F. N. Bode,Sandra Ammann,Subarna Chakravorty,Graham Davies,Jana Diestelhorst,Melissa Frei-Jones,William A. Gahl,Bernadette R. Gochuico,Matthias Griese,Gillian M. Griffiths,Gritta Janka,Christoph Klein,Tamara Kögl,Karin Kurnik,Kai Lehmberg,Andrea Maul-Pavicic,Andrew D Mumford,David Pace,Nima Parvaneh,Nima Rezaei,Geneviève de Saint Basile,Annette Schmitt-Graeff,Klaus Schwarz,Gulsun Karasu,Barbara Zieger,Udo zur Stadt,Peter Aichele,Stephan Ehl +28 more
TL;DR: HPS2 confers a risk for HLH that is lower than in Griscelli or Chediak-Higashi syndrome, probably because of a milder defect in cytotoxicity, and preemptive hematopoietic stem cell transplantation does not appear justified in HPS2.
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Graded Defects in Cytotoxicity Determine Severity of Hemophagocytic Lymphohistiocytosis in Humans and Mice
Birthe Jessen,Tamara Kögl,Fernando E. Sepulveda,Fernando E. Sepulveda,Geneviève de Saint Basile,Geneviève de Saint Basile,Geneviève de Saint Basile,Peter Aichele,Stephan Ehl +8 more
TL;DR: HLH is defined as a threshold disease determined by subtle differences in the residual lytic activity of cytotoxic T lymphocytes and their ability to control lymphocytic choriomeningitis virus, which was used as a trigger for disease induction.
Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis.
Ruth Gather,Peter Aichele,Nadja Goos,Jan Rohr,Hanspeter Pircher,Tamara Kögl,Robert Zeiser,Hartmut Hengel,Annette Schmitt-Gräff,Casey T. Weaver,Stephan Ehl +10 more
TL;DR: An alternative FHL model is established using intravenous infection of PKO mice with murine CMV (MCMV)Smith and direct comparison of the two infection models disclosed trigger‐dependence of FHL progression and revealed a higher contribution of CD4 T cells and NK cells to IFN‐γ production after MCMV infection.
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Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Tamara Kögl,Hsin Fang Chang,Julian Staniek,Samuel C C Chiang,Gudrun Thoulass,Jessica Lao,K. Weißert,Viviane Dettmer-Monaco,Kerstin Geiger,Paul T Manna,Vivien Béziat,Mana Momenilandi,Szu-Min Tu,Selina J Keppler,Varsha Pattu,Philipp Wolf,Laurence Kupferschmid,Stefan Tholen,Laura E. Covill,Karolina Ebert,Tobias Straub,Miriam Gross,Ruth Gather,Helena Engel,Ulrich Salzer,Christoph Schell,Sarah Maier,Kai Lehmberg,Tatjana I. Cornu,Hanspeter Pircher,Mohammad Shahrooei,Nima Parvaneh,Roland Elling,Marta Rizzi,Yenan T. Bryceson,Stephan Ehl,Peter Aichele,Sandra Ammann +37 more
TL;DR: STX11 deficiency leads to a secondary B cell defect characterized by hypogammaglobulinemia.
3
Immunological phenotype of the murine Lrba knockout
Laura Gámez-Díaz,Julika Neumann,Fiona Jäger,Michele Proietti,Felicitas Felber,Pauline Soulas-Sprauel,Pauline Soulas-Sprauel,Lisa Perruzza,Fabio Grassi,Fabio Grassi,Tamara Kögl,Peter Aichele,Manfred W. Kilimann,Bodo Grimbacher,Bodo Grimbacher,Sophie Jung,Sophie Jung +16 more
TL;DR: The findings expand the role of LRBA in immune regulatory mechanisms previously reported in patients, and suggest a novel role in IgA production that is crucial for the protection of mucosal surfaces and gut‐associated immune tolerance.