Tamara Hansmann
University of Würzburg
6 Papers
66 Citations
Tamara Hansmann is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 6, co-authored 6 publications.
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Papers
Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer
Tamara Hansmann,Galyna Pliushch,Monika Leubner,Patricia Kroll,Daniela Endt,Andrea Gehrig,Sabine Preisler-Adams,Peter Wieacker,Thomas Haaf +8 more
TL;DR: It is proposed that analogous to germline genetic mutations constitutive epimutations may serve as the first hit of tumor development and future strategies for effective testing of susceptibility to BC and OC should include an epimutation screen.
Monozygotic twins discordant for constitutive BRCA1 promoter methylation, childhood cancer and secondary cancer
Danuta Galetzka,Tamara Hansmann,Nady El Hajj,Eva Weis,Benjamin Irmscher,Marco Ludwig,Brigitte Schneider-Rätzke,Nicolai Kohlschmidt,Vera Beyer,O. Bartsch,U. Zechner,Claudia Spix,Thomas Haaf +12 more
TL;DR: This monozygotic twin pair represents an impressive example of epigenetic somatic mosaicism, suggesting a role for constitutive epimutations, maybe along with de novo genetic alterations in recurrent tumor development.
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Characterization of Differentially Methylated Regions in 3 Bovine Imprinted Genes: A Model for Studying Human Germ-Cell and Embryo Development
TL;DR: The identified IGF2-H19 ICR and the developed quantitative methylation assays may prove useful for further studies on the relationship between ARTs and imprinting defects in the bovine model.
DNA methylation and mRNA expression profiles in bovine oocytes derived from prepubertal and adult donors
Mike Diederich,Tamara Hansmann,Julia Heinzmann,Brigitte Barg-Kues,Doris Herrmann,Patrick Aldag,Ulrich Baulain,Richard Reinhard,Wilfried A. Kues,Christian Weissgerber,Thomas Haaf,Heiner Niemann +11 more
TL;DR: DNA methylation levels of the investigated satellite sequences were high in all groups and showed significant variation depending on the age, treatment, or in vitro maturation, and to what extent this is involved in the acquisition of developmental competence of bovine oocytes needs further study.
Epigenetic Profile of Developmentally Important Genes in Bovine Oocytes
Julia Heinzmann,Tamara Hansmann,Doris Herrmann,Christine Wrenzycki,Ulrich Zechner,Thomas Haaf,Heiner Niemann +6 more
TL;DR: The bovine oocyte is used as a model to determine putative epigenetic mutations at three imprinted gene loci caused by the type of maturation, either in vitro maturation (IVM) in Tissue Culture Medium 199 (TCM) or modified synthetic oviduct fluid (mSOF) medium, or in vivo maturation.