Tamara Brider
Ariel University
9 Papers
45 Citations
Tamara Brider is an academic researcher from Ariel University. The author has contributed to research in topics: Amonafide & Reductive amination. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Tamara Brider include Bar-Ilan University.
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Papers
One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction
TL;DR: A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines at the amine position is described, giving a fast entry to novel 9-AA derivatives for biological screening.
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Facile Synthesis of Orthogonally Protected Optically Pure Keto- and Diketopiperazine Building Blocks for Combinatorial Chemistry
Gary Gellerman,E. Hazan,E. Hazan,Tamara Brider,Tamara Brider,Tamar Traube,Tamar Traube,Amnon Albeck,S. Shatzmiler +8 more
TL;DR: These scaffolds can introduce valuable drug-like properties in three independent directions to any medicinally relevant piperazine-based motif by “around the scaffold” drug optimization by sequentially utilizing reductive alkylation, dipeptide coupling and ketopiperazine ring formation as key steps.
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Three overlooked chemical approaches toward 3-naphthalimide amonafide N-derivatives
TL;DR: In this paper, three efficient strategies for derivatization of the anticancer drug candidate amonafide (Quinamed, originally AS1413) are described, including reductive amination of aryl aldehydes, S N Ar, and addition-elimination reactions.
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Synthesis and in vitro anticancer evaluation of 1,8-naphthalimide N (4) and S (4)-derivatives combining DNA intercalation and alkylation capabilities
Tamara Brider,Boris Redko,Mor Oron-Herman,Adi Cohen-Matzlich,Gabriel Gerlitz,Gary Gellerman,Flavio Grynszpan +6 more
TL;DR: Three bi-functional 1,8-naphthalimide N(4) and S(4)-derivatives presenting both DNA intercalation and alkylation capabilities are described, indicating that these amonafide-N-mustard chimeras are effective only on certain tumor cell lines and are less toxic towards non-malignant cells than their parent drug: amonfide.
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Fiber-optic evanescent wave spectroscopy (FEWS) of crystals from a urine sample as a tool for evaluating the chemical composition of kidney stones
Refael Minnes,Tamara Brider,Andrey Goryachev,Anna Grushchenko,Ruth Tor,Amichai Nevo,David A. Lifshitz,Abraham Katzir,Yosef Raichlin +8 more
TL;DR: In this paper, the authors investigated the option of using FEWS to determine the kidney stone's composition based only on a urine sample, which revealed partial correlation between the composition of the crystals in the urine and the chemical composition of kidney calculi.
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