Talar Kechichian
University of Texas Medical Branch
51 Papers
79 Citations
Talar Kechichian is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Fetal membrane & Medicine. The author has an hindex of 12, co-authored 45 publications. Previous affiliations of Talar Kechichian include University of Texas at Austin.
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Papers
HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.
Sarah Bredeson,John Papaconstantinou,James H. DeFord,Talar Kechichian,Tariq Ali Syed,George R. Saade,Ramkumar Menon +6 more
TL;DR: HMGB1 increase by fetal membrane cells in response to either oxidative stress or infection can provide a positive feedback loop generating non-infectious inflammatory activation.
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Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia
Karin A. Fox,Monica Longo,Esther Tamayo,Talar Kechichian,Egle Bytautiene,Gary D.V. Hankins,George R. Saade,Maged M. Costantine +7 more
TL;DR: The data support a role for statins in preeclampsia prevention and pravastatin prevents vascular dysfunction in part by up-regulation of eNOS in the vasculature.
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Differential senescence in feto-maternal tissues during mouse pregnancy
Elizabeth A. Bonney,Kendall Krebs,George R. Saade,Talar Kechichian,Jayshil Trivedi,Yin Huaizhi,Ramkumar Menon +6 more
TL;DR: Telomere dependent p38 and p53 mediated senescence progressed in mouse fetal membranes as gestation advanced and may significantly contribute to mechanisms of parturition at term.
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Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth
Enkhtuya Radnaa,Lauren S. Richardson,Lauren S. Richardson,Samantha Sheller-Miller,Tuvshintugs Baljinnyam,Mariana de Castro Silva,Ananth K. Kammala,Rheanna Urrabaz-Garza,Talar Kechichian,Sungjin Kim,Arum Han,Ramkumar Menon +11 more
TL;DR: It is determined that fetal exosome mediated paracrine signaling can generate inflammation and induce parturition and in vivo functional validation of FMi-OOC experiments strengthens the reliability of such devices to test physiologic and pathologic systems.
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The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model.
Mollie McDonnold,Esther Tamayo,Talar Kechichian,Phyllis Gamble,Monica Longo,Gary D.V. Hankins,George R. Saade,Maged M. Costantine +7 more
TL;DR: Preeclampsia alters postnatal growth and metabolic function in the adult offspring in this animal model and maternal therapy with prav prevents some of these alterations in the offspring.
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