Takuya Kuroda
Foundation for Biomedical Research
21 Papers
7 Citations
Takuya Kuroda is an academic researcher from Foundation for Biomedical Research. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 11, co-authored 17 publications.
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Papers
Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells
Shugo Tohyama,Shugo Tohyama,Jun Fujita,Takako Hishiki,Tomomi Matsuura,Fumiyuki Hattori,Rei Ohno,Hideaki Kanazawa,Tomohisa Seki,Kazuaki Nakajima,Yoshikazu Kishino,Marina Okada,Akinori Hirano,Takuya Kuroda,Satoshi Yasuda,Yoji Sato,Shinsuke Yuasa,Motoaki Sano,Makoto Suematsu,Keiichi Fukuda +19 more
TL;DR: This distinguishing feature of hPSC metabolism allows preparation of clinical-grade cell sources free of undifferentiated hPSCs, which prevents tumor formation during stem cell therapy.
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TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.
Naoyuki Kitajima,Naoyuki Kitajima,Takuro Numaga-Tomita,Takuro Numaga-Tomita,Masahiko Watanabe,Takuya Kuroda,Akiyuki Nishimura,Akiyuki Nishimura,Kei Miyano,Satoshi Yasuda,Koichiro Kuwahara,Yoji Sato,Tomomi Ide,Lutz Birnbaumer,Lutz Birnbaumer,Hideki Sumimoto,Yasuo Mori,Motohiro Nishida +17 more
TL;DR: In this article, transient receptor potential canonical 3 (TRPC3), a Ca2+-permeable channel, acts as a positive regulator of ROS in cardiomyocytes, and specifically regulates pressure overload-induced maladaptive cardiac remodeling in mice.
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Takuro Numaga-Tomita,Naoyuki Kitajima,Naoyuki Kitajima,Takuya Kuroda,Akiyuki Nishimura,Akiyuki Nishimura,Kei Miyano,Satoshi Yasuda,Koichiro Kuwahara,Yoji Sato,Tomomi Ide,Lutz Birnbaumer,Lutz Birnbaumer,Hideki Sumimoto,Yasuo Mori,Motohiro Nishida +15 more
TL;DR: It is found that an inhibition of transient receptor potential canonical 3 (TRPC3) channel activity exhibited resistance to Rho-mediated maladaptive fibrosis in pressure-overloaded mouse hearts, and pharmacological TRPC3 inhibition significantly suppressed fibrotic responses in human cardiomyocytes and cardiac fibroblasts.
A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system.
TL;DR: The results indicate that the highly efficient amplification system using a combination of laminin-521 and Essential 8 medium is able to detect a trace amount of undifferentiated hPSCs contained as impurities in CTPs and would contribute to quality assessment of hPSC-derived CNPs during the manufacturing process.
SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.
Takuya Kuroda,Satoshi Yasuda,Shiori Tachi,Satoko Matsuyama,Shinji Kusakawa,Keiko Tano,Takumi Miura,Akifumi Matsuyama,Yoji Sato +8 more
TL;DR: It is determined that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias and reduced mesoderm/endoderm due to DNMT3B mediated DNA methylation.
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