Takeuchi Tomoki
Taisho Pharmaceutical Co.
6 Papers
1 Citations
Takeuchi Tomoki is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Topoisomerase IV & DNA gyrase. The author has an hindex of 2, co-authored 6 publications.
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Papers
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
Fumihito Ushiyama,Hideaki Amada,Takeuchi Tomoki,Nozomi Tanaka-Yamamoto,Harumi Kanazawa,Koichiro Nakano,Masashi Mima,Aiko Masuko,Iichiro Takata,Kosuke Hitaka,Kunihiko Iwamoto,Hiroyuki Sugiyama,Norikazu Ohtake +12 more
- 24 Apr 2020
TL;DR: Hit-to-lead (H2L) chemistry is applied for the identification of a new chemical class of GyrB/ParE inhibitors by efficient use of thermodynamic parameters and advanced into further optimization for creating novel antibacterial agents.
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Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
Fumihito Ushiyama,Hideaki Amada,Yasuhiro Mihara,Takeuchi Tomoki,Nozomi Tanaka-Yamamoto,Masashi Mima,Masafumi Kamitani,Reiko Wada,Yunoshin Tamura,Mayumi Endo,Aiko Masuko,Iichiro Takata,Kosuke Hitaka,Hiroyuki Sugiyama,Norikazu Ohtake +14 more
TL;DR: TP0480066 can be regarded as a promising antibacterial drug candidate of this chemical class and is aimed at creating novel antibacterial agents against bacterial type II topoisomerases, which are well-validated targets.
10
Patent
2(1h)-quinolinone derivative
Hideaki Amada,Otake Norikazu,Fumihito Ushiyama,Kim Chunhae,Takeuchi Tomoki,Tanaka Nozomi +5 more
- 27 Sep 2018
TL;DR: In this article, a 2(1h)-quinolinone derivative represented by formula (1) or a pharmaceutically acceptable salt thereof was proposed to provide a useful novel compound exhibiting antimicrobial activity on the basis of inhibitory action of DNA gyrase GyrB and topoisomerase IV ParE.
1
Patent
Pyrazolo[1,5-a]pyrimidine macrocyclic compound
Takanori Kawaguchi,Yuya Ogata,Tanaka Nozomi,Takeuchi Tomoki,Sasaki Toru,Ryo Takahashi,Hatanaka Kanako,Tsuruta Risa,Tamaoki Tomokazu +8 more
- 02 Jul 2020
TL;DR: In this article, a novel compound that is useful for treating or preventing infections associated with viruses belonging to the subfamily Pneumovirinae, including respiratory syncytial virus (RSV), and that has an anti-RSV activity; or a pharmaceutically acceptable salt thereof.
Patent
2(1h)-퀴놀리논 유도체
Hideaki Amada,Otake Norikazu,Fumihito Ushiyama,Kim Chunhae,Takeuchi Tomoki,Tanaka Nozomi +5 more
- 03 Dec 2019
TL;DR: DNA as mentioned in this paper : GyrB 토포이소메라아제 IV의 ParE 저해 작용에 기초하여 항균 활성을 나타내는