Takeru Oka
Kyushu University
5 Papers
6 Citations
Takeru Oka is an academic researcher from Kyushu University. The author has contributed to research in topics: Medicine & Phosphorylation. The author has an hindex of 2, co-authored 2 publications.
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Papers
Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium
Tsunaki Higa,Yasutaka Okita,Akinobu Matsumoto,Shogo Nakayama,Takeru Oka,Osamu Sugahara,Daisuke Koga,Shoichiro Takeishi,Hirokazu Nakatsumi,Naoki Hosen,Sylvie Robine,Makoto Mark Taketo,Toshiro Sato,Keiichi I. Nakayama +13 more
TL;DR: In this paper , the authors identify the cyclin-dependent kinase inhibitor p57 as a specific marker for a quiescent cell population located around the +4 position of intestinal crypts, which serve as enteroendocrine/tuft cell precursors under normal conditions but dedifferentiate and act as facultative stem cells to support regeneration after injury.
The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis
Yasuyuki Kita,Yasuyuki Kita,Yuta Katayama,Taichi Shiraishi,Takeru Oka,Tetsuya Sato,Mikita Suyama,Yasuyuki Ohkawa,Keishi Miyata,Yuichi Oike,Michiko Shirane,Michiko Shirane,Masaaki Nishiyama,Masaaki Nishiyama,Keiichi I. Nakayama +14 more
TL;DR: This paper showed that CHD8 interacts with CCAAT/enhancer-binding protein β (C/EBPβ) and promotes its transactivation activity during adipocyte differentiation.
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Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Hirokazu Nakatsumi,Hirokazu Nakatsumi,Takeru Oka,Tsunaki Higa,Michiko Shirane,Michiko Shirane,Keiichi I. Nakayama +6 more
TL;DR: It is shown that a nuclear–cytoplasmic transport system is necessary for the mTORC1‐FOXK1 signal transduction and that PP2AB56 phosphatase contributes to the signaling for mTORc1‐dependent transcriptional regulation.
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Antitumor Activity of Tumor-Infiltrating Neutrophils Revealed by a Syngeneic Mouse Model of Cholangiocarcinoma.
Osamu Sugahara,Daisuke Koga,Takeru Oka,Shigeaki Sugiyama,Reona Wada,Tsunaki Higa,Keiichi I. Nakayama +6 more
TL;DR: This study reveals antitumor activity of tumor-infiltrating neutrophils in a syngeneic mouse model of cholangiocarcinoma, mediated by reactive oxygen species production, and demonstrates therapeutic potential of targeting neutrophils with recombinant human granulocyte colony-stimulating factor.
Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence After Chemotherapy of Intestinal Tumors.
TL;DR: In this paper , the authors established a syngeneic orthotopic transplantation model in mice based on intestinal cancer organoids to profile quiescent cancer stem cells (CSCs) and reveal p57+ CSCs as a promising therapeutic target for malignant intestinal cancer.