Takeo Ono
Taisho Pharmaceutical Co.
6 Papers
70 Citations
Takeo Ono is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: In vivo & Josamycin. The author has an hindex of 4, co-authored 6 publications.
Chat about Author
Papers
Chemical modification of erythromycins. III. In vitro and in vivo antibacterial activities of new semisynthetic 6-O-methylerythromycins A, TE-031 (clarithromycin) and TE-032.
Shigeo Morimoto,Takatoshi Nagate,Kazuhiko Sugita,Takeo Ono,Kazuo Numata,Junko Miyachi,Yoko Misawa,Kenji Yamada,Sadafumi Omura +8 more
TL;DR: The therapeutic efficacies of TE-031 and TE-032 against systemic and subcutaneous infections provoked by Gram-positive bacteria in mice are 4- to 35-fold superior to those of EM and JM.
25
In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs.
Takeo Ono,Masato Kashimura,Keiko Suzuki,Rika Oyauchi,Junko Miyachi,Hiroshi Ikuta,Hiroyuki Kawauchi,Toshi Akashi,Toshifumi Asaka,Shigeo Morimoto +9 more
TL;DR: The therapeutic efficacies of TKs against systemic infections and respiratory tract infection (RTI) caused by gram-positive bacteria in mice are superior to those of CAM and AZM, and the pharmacokinetics of TE-802 are similar to Those of AZM in mice and monkeys, suggesting the potential for once-daily administration in humans.
23
Structure-activity relationship study of 6-O-Methylerythromycin 9-O-substituted oxime derivatives
Yutaka Kawashima,Yuki Yamada,Toshifumi Asaka,Yoko Misawa,Masato Kashimura,Sigeo Morimoto,Takeo Ono,Takatoshi Nagate,Katsuo Hatayama,Shuichi Hirono,Ikuo Moriguchi +10 more
TL;DR: In QSARs of 6-O-methyl EM-A 9- O-substituted oxime derivatives, the difference of the contribution of log P to the antibacterial activity between EM-resistant and susceptible strains was clearly recognized.
12
In vitro and in vivo Antibacterial Activities of Clarithromycin
TL;DR: Therapeutic efficacies of CAM against various experimental infections in mice were superior to those of EM, JM and RKM, and CAM exhibited higher serum levels than EM in mice after a single oral dose of 50 mg/kg.
4