Takayoshi Suga
Gunma University
13 Papers
12 Citations
Takayoshi Suga is an academic researcher from Gunma University. The author has contributed to research in topics: Medicine & Glucagon secretion. The author has an hindex of 3, co-authored 9 publications.
Chat about Author
Papers
SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels
Takayoshi Suga,Osamu Kikuchi,Masaki Kobayashi,Sho Matsui,Hiromi Yokota-Hashimoto,Eri Wada,Daisuke Kohno,Tsutomu Sasaki,Kazusane Takeuchi,Satoru Kakizaki,Masanobu Yamada,Tadahiro Kitamura +11 more
TL;DR: A glucose clamp study revealed that the plasma glucagon increase associated with dapagliflozin could be explained as a response to acute declines in blood glucose, and suggested that a novel mechanism regulated glucagon secretion through SGLT1 in α cells.
91
SGLT1 in Pancreatic a Cells Regulates Glucagon Secretion in Mice, Possibly Explaining the Distinct Effects of SGLT2 Inhibitors on Plasma Glucagon Levels
Takayoshi Suga,Osamu Kikuchi,Masaki Kobayashi,Sho Matsui,Hiromi H. Hashimoto,Tsutomu Sasaki,Satoru Kakizaki,Masanobu Yamada,Tadahiro Kitamura +8 more
TL;DR: It is shown that dapagliflozin, but not canag liflozin which is a SGLT2/low-potency-SGLT1 inhibitor, increased plasma glucagon levels in mice fed a high-fat, high-sucrose diet (HFHSD) and diabetic db/db mice and showed that the S GLT1 effect on glucagon secretion depended on sodium/glucose cotransport, but on metabolic effect of glucose.
23
Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.
Eri Wada,Masaki Kobayashi,Daisuke Kohno,Osamu Kikuchi,Takayoshi Suga,Sho Matsui,Hiromi Yokota-Hashimoto,Norikiyo Honzawa,Yuichi Ikeuchi,Haruka Tsuneoka,Touko Hirano,Hideru Obinata,Tsutomu Sasaki,Tadahiro Kitamura +13 more
TL;DR: In this article, the effects of nutrients on glucagon secretion were assessed using islets isolated from diabetic mice and palmitate-treated islets, and the expression levels of branched chain amino acid (BCAA) catabolism-related enzymes and their metabolites in diabetic islets.
19
Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling.
Takayoshi Suga,Ken Sato,Tatsuya Ohyama,Sho Matsui,Takeshi Kobayashi,Hiroki Tojima,Norio Horiguchi,Yuichi Yamazaki,Satoru Kakizaki,Ayaka Nishikido,Takashi Okamura,Masanobu Yamada,Tadahiro Kitamura,Toshio Uraoka +13 more
TL;DR: The study suggests that the liver steatosis-ameliorating effects of ipragliflozin in ob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly through the PGC-1α/PPARα-FGF21 pathway.
12
Adolescents with chronic hepatitis C might be good candidates for direct‐acting antiviral therapy
Ken Sato,Yuichi Yamazaki,Yuki Kanayama,Daisuke Uehara,Hiroki Tojima,Takayoshi Suga,Satoru Kakizaki,Naondo Sohara,Norio Horiguchi,Toshio Uraoka +9 more
TL;DR: Three Japanese adolescents with chronic hepatitis C were treated by direct‐acting antivirals (DAAs) and the emotional functioning of the patients and their mothers were improved after DAA therapy.
2