Takayoshi Nakano

TL;DR: Angiotensin II‐dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation in CKD and contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD.

TL;DR: Not only BMD but also BAp alignment changes depending on the applied stress on the basis of the functional adaptation in bones, which suggests that theBAp alignment is sensitively controlled by the bending stress in addition to the axial stress along the long bone.

TL;DR: It is hypothesized that hydrogel with different mechanical stiffness can provide a biomimetic mechanical environment that can modulate bone tissue growth and mineralization and would be one of the unique models for better understanding the mineralized tissue development.

TL;DR: Changes in bone mineral density (BMD) and preferential alignment of biological apatite (BAp) were examined focusing on the role of osteoblast using the model of osteopetrotic (op/op) mice, suggesting that the decrease in the number of osteoclasts suppresses normal remodeling, resulting in a decrease in bone quality.