Takayasu Ito
Nagoya University
39 Papers
669 Citations
Takayasu Ito is an academic researcher from Nagoya University. The author has contributed to research in topics: Medicine & Rheumatoid arthritis. The author has an hindex of 17, co-authored 29 publications. Previous affiliations of Takayasu Ito include Tokai University.
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Papers
Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: Analyses of synovial fluid from patients with osteoarthritis
TL;DR: A link between proteolysis and inhibitor concentrations in OA cartilage suggests that there is a measurable loss of cartilage in the late stages of the disease, and the resultant composition of the cartilage suggest that the loss may primarily involve "resident" molecules originally present in healthy cartilage.
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•Journal Article
Determination of stromelysin-1,72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1(TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis
TL;DR: It would seem that regulation of TIMP production depends upon the disease state and not the concentration of MMP, which may be responsible for cartilage destruction in RA.
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Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis.
Naoki Ishiguro,Takayasu Ito,Takeshi Oguchi,Toshihisa Kojima,Hisashi Iwata,Mirela Ionescu,A. Robin Poole +6 more
TL;DR: The observations provide new insights into the complex changes in cartilage turnover and PMN influx in RA joints and suggest that HA and PMNs may be involved in the control of proteolysis and cartilage proteoglycan assembly.
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Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components
Naoki Ishiguro,Toshihisa Kojima,Takayasu Ito,Shinsuke Saga,Hideki Anma,Kazutoshi Kurokouchi,Yuusuke Iwahori,Toshiki Iwase,Hisashi Iwata +8 more
TL;DR: Debris released from implants appears to cause activation of macrophages and the production of inflammatory cytokines and chemokines that induce cellular recruitment into interface tissue that might form a vicious cycle that aggravates THA loosening.
74
•Journal Article
The SHAP-HA complex in sera from patients with rheumatoid arthritis and osteoarthritis.
D Kida,M Yoneda,S Miyaura,T Ishimaru,Y Yoshida,Takayasu Ito,Naoki Ishiguro,Hisashi Iwata,Koji Kimata +8 more
TL;DR: Quantitation of the SHAP-HA complex in sera may be useful as a joint marker that directly correlates to the degree of joint inflammation in RA, and offers new insight into the pathogenesis of arthritis.
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