Takashi Yugawa
National Cancer Research Institute
44 Papers
222 Citations
Takashi Yugawa is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Carcinogenesis & Biology. The author has an hindex of 21, co-authored 36 publications.
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Papers
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins
Takashi Yugawa,Tohru Kiyono +1 more
TL;DR: It is crucial that molecular details of the natural history of HPV infection as well as the biological activities of the viral oncoproteins be elucidated in order to provide the basis for development of new therapeutic strategies against HPV‐associated malignancies.
251
Regulation of Notch1 gene expression by p53 in epithelial cells.
Takashi Yugawa,Keisuke Handa,Mako Narisawa-Saito,Shin Ichi Ohno,Masatoshi Fujita,Tohru Kiyono +5 more
TL;DR: A novel link between p53 and Notch1 in keratinocyte differentiation upon genotoxic stress is demonstrated and a novel tumor suppressor mechanism of p53 in the development of squamous cell carcinomas, including HPV-induced tumors is suggested.
205
Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.
Rumi Sasaki,Mako Narisawa-Saito,Takashi Yugawa,Masatoshi Fujita,Hironori Tashiro,Hidetaka Katabuchi,Tohru Kiyono +6 more
TL;DR: Results indicate that inactivation of p53 and activation of the Ras pathway play critical roles in ovarian carcinogenesis in co-operation with the Akt or c-myc pathways.
Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
Kei Haga,Shin Ichi Ohno,Takashi Yugawa,Mako Narisawa-Saito,Masatoshi Fujita,Michiie Sakamoto,Denise A. Galloway,Tohru Kiyono +7 more
TL;DR: Evidence is presented that many human cell types undergo senescence by activation of the p16ink4a/Rb pathway, and that introduction of Bmi‐1 can inhibit p16INK4a expression and extend the life span of human epithelial cells derived from skin, mammary gland and lung.
99
The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome
Nagayasu Egawa,Tomomi Nakahara,Shin Ichi Ohno,Mako Narisawa-Saito,Takashi Yugawa,Masatoshi Fujita,Kenji Yamato,Yukikazu Natori,Tohru Kiyono +8 more
TL;DR: It is demonstrated that the E1 protein is dispensable for maintenance replication but not for initial and productive replication of HPV16.
84