Takahiro Uchida
Tokyo Medical University
29 Papers
86 Citations
Takahiro Uchida is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Medicine & Renal biopsy. The author has an hindex of 8, co-authored 29 publications. Previous affiliations of Takahiro Uchida include National Defense Medical College.
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Papers
Renoprotective effects of a dipeptidyl peptidase 4 inhibitor in a mouse model of progressive renal fibrosis.
Takahiro Uchida,Takashi Oda,Hidehito Matsubara,Atsushi Watanabe,Hanako Takechi,Naoki Oshima,Yutaka Sakurai,Hiroo Kumagai +7 more
TL;DR: Alogliptin exerted renoprotective antifibrotic effects and DPP-4 inhibitors may be promising therapeutic choices even for nondiabetic CKD patients, suggesting an anti-inflammatory action by the D PP-4 inhibitor.
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Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury
Takahiro Uchida,Takahiro Uchida,Seigo Ito,Hiroo Kumagai,Takashi Oda,Hiroyuki Nakashima,Shuhji Seki +6 more
TL;DR: Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver that are assumed to be involved in various renal diseases, and there may be complementary roles shared between NKT and NK cells.
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Glomerular Deposition of Nephritis-Associated Plasmin Receptor (NAPlr) and Related Plasmin Activity: Key Diagnostic Biomarkers of Bacterial Infection-related Glomerulonephritis.
Takahiro Uchida,Takashi Oda +1 more
TL;DR: Recent advances in the understanding of the pathogenesis of bacterial IRGN are discussed, which is characterized by NAPlr and plasmin as key biomarkers.
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Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice.
Takahiro Uchida,Hiroyuki Nakashima,Akira Yamagata,Seigo Ito,Takuya Ishikiriyama,Masahiro Nakashima,Shuhji Seki,Hiroo Kumagai,Naoki Oshima +8 more
TL;DR: Results suggest that α-GalCer suppressed Th2 immune responses in NKT cells and B cell function, thereby slowing the progression of lupus nephritis.
Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56 + T cells.
Takahiro Uchida,Hiroyuki Nakashima,Seigo Ito,Takuya Ishikiriyama,Masahiro Nakashima,Shuhji Seki,Hiroo Kumagai,Naoki Oshima +7 more
TL;DR: It is shown that α-GalCer-activated mouse NKT cells injured both kidney vascular endothelial cells and tubular epithelial cells in vitro, causing acute kidney injury (AKI) with hematuria in middle-aged mice, and targeting CD56+ T cells may be a promising approach to treat AKI.
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