Takahiro Kitamura
Daiichi Sankyo
5 Papers
10 Citations
Takahiro Kitamura is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Antibacterial activity & PKM2. The author has an hindex of 4, co-authored 5 publications.
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Papers
Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.
Takashi Odagiri,Hiroaki Inagaki,Yuichi Sugimoto,Masatoshi Nagamochi,Rie Miyauchi,Junichi Kuroyanagi,Takahiro Kitamura,Satoshi Komoriya,Hisashi Takahashi +8 more
TL;DR: Compound 2a showed excellent in vivo activity against the experimental murine pneumonia model due to multidrug resistant Streptococcus pneumoniae (MDRSP) and favorable profiles in preliminary toxicological and nonclinical pharmacokinetic studies.
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Design, Synthesis, and Biological Evaluation of Novel 7-[(3aS,7aS)-3a-Aminohexahydropyrano[3,4-c]pyrrol-2(3H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens
Takashi Odagiri,Hiroaki Inagaki,Masatoshi Nagamochi,Takahiro Kitamura,Satoshi Komoriya,Hisashi Takahashi +5 more
TL;DR: The reduced lipophilicity and basicity of compound 5 as compared to those of the previously synthesized carba-type compound 4 resulted in a significant reduction in the human ether-a-go-go (hERG) related gene channel inhibition, which have the potential to prolong the QT interval.
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Discovery of Novel 7-[(1R,5S)-1-Amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropane]-8-(methoxy or methyl)quinolones.
Satoshi Komoriya,Takashi Odagiri,Hiroaki Inagaki,Masatoshi Nagamochi,Rie Miyauchi,Yoshida Kenichi,Takahiro Kitamura,Hisashi Takahashi +7 more
TL;DR: Novel 8-methylquinolone 7, which includes a 3-amino-7-fluorooctahydrocyclopenta[c]pyrrole moiety at the C-7 position, showed potent antibacterial activity against both Gram-positive and negative pathogens.
7
Patent
Fused substituted aminopyrrolidine derivative
Hisashi Takahashi,Satoshi Komoriya,Takahiro Kitamura,Takashi Odagiri,Hiroaki Inagaki,Tsuda Toshifumi,Kiyoshi Nakayama,Makoto Takemura,Yoshida Kenichi,Rie Miyauchi,Masatoshi Nagamochi +10 more
- 28 Dec 2007
TL;DR: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided in this paper, which has strong antibacterial activity not only to Gramnegative bacteria but also to Gram-positive cocci that have low sensitivity to quinoline antibacterial agents, and exhibits high safety and excellent pharmacokinetics.
6
Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator
Yumi Matsui,Isao Yasumatsu,Takashi Asahi,Takahiro Kitamura,Kazuo Kanai,Osamu Ubukata,Hitoshi Hayasaka,Sachiko Takaishi,Hiroyuki Hanzawa,Shin-ichi Katakura +9 more
TL;DR: Discovery of this novel scaffold and binding mode of the linked compound provides a valuable platform for the structure-guided design of PKM2 activators.