Tak Mao Chan
University of Hong Kong
401 Papers
3K Citations
Tak Mao Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Medicine & Lupus nephritis. The author has an hindex of 59, co-authored 388 publications. Previous affiliations of Tak Mao Chan include Pamela Youde Nethersole Eastern Hospital & Queen Mary Hospital.
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Papers
miR-200c Prevents TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1
Jessica Y. S. Chu,Mel K. M. Chau,Caleb C.Y. Chan,Andrew Tai,Kwok Fan Cheung,Tak Mao Chan,Susan Yung +6 more
TL;DR: It is demonstrated that miR-200c regulates EMT and fibrogenesis in mesothelial cells, and loss of peritoneal miR -200c contributes to PD-associated peritoneAL fibrosis.
Conversion of ciclosporin A to tacrolimus in kidney transplant recipients with chronic allograft nephropathy
Sydney C.W. Tang,Kwok Wah Chan,Colin S.O. Tang,Man Fai Lam,C.Y. Leung,Kai Chung Tse,Chun Sang Li,Yiu Wing Ho,Matthew K.L. Tong,Kar Neng Lai,Tak Mao Chan +10 more
TL;DR: The results suggest that in patients with CAN and deteriorating allograft function, CsA-to-tacrolimus conversion or CSA minimization achieved comparable efficacies in retarding the decline of graft function.
Gene-based meta-analysis of genome-wide association study data identifies independent single-nucleotide polymorphisms in ANXA6 as being associated with systemic lupus erythematosus in Asian populations.
Jing Zhang,Lu Zhang,Yan Zhang,Jing Yang,Mengbiao Guo,Liangdan Sun,Hai-Feng Pan,Nattiya Hirankarn,Dingge Ying,S. Zeng,Tsz Leung Lee,Chak Sing Lau,Tak Mao Chan,Alexander Moon Ho Leung,Chi Chiu Mok,Sik Nin Wong,KW Lee,Marco Ho,Pamela Pui Wah Lee,Brian H.Y. Chung,Chun Yin Chong,Raymond Woon Sing Wong,Mo Yin Mok,Wilfred Hing Sang Wong,Kwok Lung Tong,Niko Kei Chiu Tse,Xiang-Pei Li,Yingyos Avihingsanon,Pornpimol Rianthavorn,Thavatchai Deekajorndej,Kanya Suphapeetiporn,Vorasuk Shotelersuk,Shirley King Yee Ying,Samuel Ka Shun Fung,Wai Ming Lai,Maria-Mercè Garcia-Barceló,Stacey S. Cherny,Pak C. Sham,Yong Cui,Sen Yang,Dong-Qing Ye,Xuejun Zhang,Yu-Lung Lau,Wanling Yang +43 more
TL;DR: This study investigated whether using a gene‐based analysis may help to identify novel loci, by considering global evidence of association from a gene or a genomic region rather than focusing on evidence for individual variants.
Histological reclassification of lupus nephritis
TL;DR: The ISN/RPS 2003 classification facilitates accurate communication between pathologists and clinicians and provides a clear framework for standardization, upon which the clinical and pathogenetic significance of individual lesions and histological subtypes require further elucidation.
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Treatment of lupus nephritis: practical issues in Asian countries
Desmond Y H Yap,Tak Mao Chan +1 more
TL;DR: There is substantial data confirming the efficacy of combined corticosteroids and either cyclophosphamide or mycophenolate mofetil (MMF) as initial treatments for active Class III/IV LN in Asian patients, and the optimal choice needs to take into account tolerability and prior induction therapy.
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