Tak Mao Chan
University of Hong Kong
401 Papers
3K Citations
Tak Mao Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Medicine & Lupus nephritis. The author has an hindex of 59, co-authored 388 publications. Previous affiliations of Tak Mao Chan include Pamela Youde Nethersole Eastern Hospital & Queen Mary Hospital.
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Papers
Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria.
TL;DR: It is concluded that ACEI/ARB effectively reduces proteinuria and improves serum albumin in patients with persistent proteinuria despite quiescent lupus nephritis.
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Interferon treatment for hepatitis C virus infection in patients on haemodialysis.
TL;DR: Eradication of chronic HCV infection with IFN can be achieved in 27% of haemodialysis patients, and predictors of sustained response include low baseline HCV RNA level and mild liver pathology.
Intrinsic Cells: Mesothelial Cells — Central Players in Regulating Inflammation and Resolution:
Susan Yung,Tak Mao Chan +1 more
TL;DR: Far from being bystanders in peritoneal function, mesothelial cells have been shown to play a dynamic role inperitoneal homeostasis and immunoregulation and may provide novel therapeutic strategies for the preservation of the peritoneum during PD.
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Mesangial Cell-Binding Anti-DNA Antibodies in Patients with Systemic Lupus Erythematosus
TL;DR: Subsets of anti-DNA antibodies from patients with SLE are capable of binding to human mesangial cells (HMC) in vitro, and the association of such binding with renal involvement and disease activity and its modulation by DNA concentration suggest that Ig binding to HMC can be a potential marker for disease activity in selected patients and that the binding ofAnti- DNA antibodies to H MC may be a pathogenetic mechanism in LN.
Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications
Yu Liu,Jieyue Liao,Ming Zhao,Haijing Wu,Susan Yung,Tak Mao Chan,Akihiko Yoshimura,Qianjin Lu +7 more
TL;DR: It is demonstrated that increased expression of TLR2 contributes to immune reactivity and promotes IL‐17A and IL‐ 17F expression through histone modifications in SLE.
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