Taha Merghoub

TL;DR: These studies demonstrate how rationally designed DNA vaccines directed against self antigens for enhanced antigen processing and presentation reveal novel self epitopes and elicit multi-specific T cell responses to nonimmunogenic, nonmutated self antIGens, enhancing immunity against cancer self antigelens.

TL;DR: In this article , the authors investigate how 70 human pancreatic cancers evolved over 10 years and find that rare long-term survivors of pancreatic cancer who have stronger T cell activity in primary tumours develop genetically less heterogeneous recurrent tumours with fewer immunogenic mutations (neoantigens).

TL;DR: It is found that despite the specificity of the soluble Fab, the same antibody in the form of a CAR caused moderate lysis of HLA-A2 expressing targets independent of antigen owing to T cell avidity, and there is exciting potential for CARs to expand their repertoire to include a broad range of intracellular antigens.

TL;DR: Cancer exome data obtained from a previously published study of 64 melanoma patients treated with CTLA-4 blockade and a new dataset of RNA-Seq data from 24 of those patients are reanalyzed and it is found that the predictive accuracy does not increase as analysis narrows from somatic mutation burden to predicted MHC Class I neoantigens, expressed neoantIGens, or homology to pathogens.