Tadayoshi Karasawa
Jichi Medical University
60 Papers
57 Citations
Tadayoshi Karasawa is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Inflammasome & Inflammation. The author has an hindex of 24, co-authored 49 publications. Previous affiliations of Tadayoshi Karasawa include Japanese Foundation for Cancer Research.
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Papers
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Takashi Matsuzaka,Hitoshi Shimano,Naoya Yahagi,Naoya Yahagi,Toyonori Kato,Ayaka Atsumi,Takashi Yamamoto,Noriyuki Inoue,Mayumi Ishikawa,Sumiyo Okada,Naomi Ishigaki,Hitoshi Iwasaki,Yuko Iwasaki,Tadayoshi Karasawa,Shin Kumadaki,Toshiyuki Matsui,Motohiro Sekiya,Ken Ohashi,Alyssa H. Hasty,Yoshimi Nakagawa,Akimitsu Takahashi,Hiroaki Suzuki,Sigeru Yatoh,Hirohito Sone,Hideo Toyoshima,Jun-ichi Osuga,Nobuhiro Yamada +26 more
TL;DR: Hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress and could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
Role of NLRP3 Inflammasomes in Atherosclerosis.
TL;DR: The present state of knowledge on the role of NLRP3 inflammasomes in the pathogenesis of atherosclerosis is reviewed and the therapeutic approaches that target NLRP2 inflammaomes are discussed.
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure
Naoya Yamada,Tadayoshi Karasawa,Hiroaki Kimura,Sachiko Watanabe,Takanori Komada,Ryo Kamata,Ariunaa Sampilvanjil,Junya Ito,Kiyotaka Nakagawa,Hiroshi Kuwata,Shuntaro Hara,Koichi Mizuta,Yasunaru Sakuma,Naohiro Sata,Masafumi Takahashi +14 more
TL;DR: It is found that lipid peroxides derived from n-6 fatty acids, mainly arachidonic acid, were elevated by APAP, and that auto-oxidation is the predominant mechanism of APAP-derived lipid oxidation.
Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis.
Naoya Yamada,Tadayoshi Karasawa,Taiichi Wakiya,Ai Sadatomo,Homare Ito,Ryo Kamata,Sachiko Watanabe,Takanori Komada,Hiroaki Kimura,Yukihiro Sanada,Yasunaru Sakuma,Koichi Mizuta,Nobuhiko Ohno,Naohiro Sata,Masafumi Takahashi +14 more
TL;DR: It is demonstrated that iron overload is a novel risk factor for hepatic I/R injury in LT, and ferroptosis contributes to the pathogenesis of hepatic ischemia‐reperfusion injury.
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Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II–Induced Aortic Aneurysm
Fumitake Usui,Koumei Shirasuna,Hiroaki Kimura,Kazuki Tatsumi,Akira Kawashima,Tadayoshi Karasawa,Koichi Yoshimura,Hiroki Aoki,Hiroko Tsutsui,Tetsuo Noda,Junji Sagara,Shun'ichiro Taniguchi,Masafumi Takahashi +12 more
TL;DR: The results demonstrate the importance of the NLRP3 inflammasome in the initial inflammatory responses in AAA formation, indicating its potential as a novel therapeutic target for preventing AAA progression.
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