Tadashi Inagami
Vanderbilt University
427 Papers
7.1K Citations
Tadashi Inagami is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 91, co-authored 426 publications. Previous affiliations of Tadashi Inagami include Yale University & Max Delbrück Center for Molecular Medicine.
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Papers
Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.
TL;DR: The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library and showed a high degree of sequence identity to bovine and rat AT1 receptor sequences.
Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.
Mitsuhide Naruse,Tadashi Inagami +1 more
TL;DR: The results suggest possible involvement of adrenal renin in the development and in the early maintenance phase of hypertension in this animal mode of human essential hypertension by affecting the adrenocortical or adrenomedullary activity, or both.
The rat angiotensin II AT1A receptor couples with three different signal transduction pathways.
TL;DR: It is suggested that the rat AT1A receptor can independently couple with all three signal transduction pathways known to be induced by AII: i.e., activation of phospholipase C resulting in InsP3 generation with a subsequent release of intracellularly stored Ca2+, ii) activation of dihydropyridine-sensitive voltage-dependent Ca2+ channels, and iii) inhibition of adenylate cyclase activity.
Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats.
TL;DR: The results suggest that the vascular renin-angiotensin system plays an important role in the maintenance of two-kidney, one clip hypertension.
Calcitonin receptor gene polymorphism in japanese women: correlation with body mass and bone mineral density.
Misa Nakamura,Shigeto Morimoto,Z. Zhang,Hirotoshi Utsunomiya,Tadashi Inagami,Toshio Ogihara,Kennichi Kakudo +6 more
TL;DR: The CTR allele is one of the genetic factors regulating body weight in Japanese women and was found that C allele was predominant in the Japanese population, however, Caucasians have an almost equal ratio of the C and T.