14 Papers
Tad Eichler is an academic researcher from The Research Institute at Nationwide Children's Hospital. The author has contributed to research in topics: RNase P & Medicine. The author has an hindex of 7, co-authored 9 publications.
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Papers
Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses
Matthew J. Murtha,Matthew J. Murtha,Tad Eichler,Kristin Bender,Jackie Metheny,Birong Li,Andrew L. Schwaderer,Andrew L. Schwaderer,Andrew L. Schwaderer,Claudia Mosquera,Cindy James,Laura Schwartz,Brian Becknell,Brian Becknell,Brian Becknell,John David Spencer,John David Spencer,John David Spencer +17 more
TL;DR: Data suggest that insulin signaling plays a critical role in renal antibacterial defenses, and insulin receptor–mediated signaling regulates AMPs, including lipocalin 2 and ribonuclease 4, via phosphatidylinositol-3-kinase signaling.
Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections.
Keith R. Pierce,Tad Eichler,Claudia Mosquera Vasquez,Andrew L. Schwaderer,Aaron Simoni,Steven Creacy,David S. Hains,John David Spencer +7 more
TL;DR: In this article, the authors determined whether the RNASE7 SNP rs1263872 is more prevalent in children with UTI and defined how rs 1263872 affects RNase 7's antimicrobial activity against uropathogenic E. coli (UPEC).
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Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection
Laura Schwartz,Matthew S. Bochter,Aaron Simoni,Kristin Bender,Juan de Dios Ruiz Rosado,Israel Cotzomi-Ortega,Yuriko Itzel Sánchez-Zamora,Brian Becknell,Sarah Linn,Birong Li,Nicholas Santoro,Tad Eichler,John David Spencer +12 more
TL;DR: Ribonuclease 4 and 7 are host defense peptides produced by the kidney and bladder and exhibit bactericidal activity against uropathogenic bacteria and antibiotic-resistant bacteria as discussed by the authors .
14
Lumican modulates adipocyte function in obesity-associated type 2 diabetes
Clarissa Strieder-Barboza,Carmen G. Flesher,Lynn M. Geletka,Tad Eichler,Olukemi P. Akinleye,Alexander Ky,Annerose Ehlers,Carey N. Lumeng,Robert W. O’Rourke +8 more
TL;DR: In this paper , the effects of lumican on adipocyte function were studied using human visceral adipose tissue (VAT) from subjects with and without type 2 diabetes (DM) and they demonstrated that lumican impairs adipocyte metabolism, partially via ERK signalling, and is a potential target for developing adipocyte-targeted therapeutics in DM.
8
Patent
Rnase7 for treatment of bacterial infection
John David Spencer,Tad Eichler +1 more
- 04 Nov 2016
TL;DR: In this article, a method of treating or preventing bacterial infection in a subject having metabolic syndrome, insulin resistance, or diabetes mellitus is described, which includes administering a therapeutically effective amount of RNAse 7 and/or a PI3K/AKT agonist to the subject.