Tabitha Rücker
5 Papers
Tabitha Rücker is an academic researcher. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 1, co-authored 3 publications.
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Papers
Protocol for differential multi-omic analyses of distinct cell types in the mouse cerebral cortex
Durga Praveen Meka,Melanie Richter,Tabitha Rücker,Hannah Voß,Anne Rissiek,Christoph Krisp,Nisha Hemandhar Kumar,Birgit Schwanke,Eugenio F. Fornasiero,Hartmut Schlüter,Froylan Calderon de Anda +10 more
TL;DR: This protocol can be applied to compare the proteomes and transcriptomes of developing mouse cortical cell populations after various manipulations (e.g., epigenetic) and is applicable to compare the proteomes and transcriptomes of developing mouse cortical cell populations after various manipulations.
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Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,Matthias Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K. Singh,Kent E. Duncan,Froylan Calderon de Anda +18 more
TL;DR: This work aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the response of the immune system to EMTs.
TAOK2β represses translation via phosphorylation of eEF2 and ameliorates exaggerated protein synthesis in a mouse model of 16p11.2 microdeletion-driven autism
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,Matthias Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K. Singh,Kent E. Duncan,Froylan Calderon de Anda +18 more
TL;DR: The results uncover a critical role of TAOK2β as a regulator of protein synthesis and support the idea that translational control is a common endpoint of ASD-associated signaling pathways.
The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Shuai Hong,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,M. Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K Singh,Kent E Duncan,Froylan Calderon de Anda +19 more
TL;DR: It is shown that TAOK2 can directly phosphorylate eEF2 on the same regulatory site, but functions independently of eEF2K signaling, which suggests an eEF2K-independent signaling pathway for control of translation elongation.
TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model
Robin Scharrenberg,Melanie Richter,Ole Johanns,Durga Praveen Meka,Tabitha Rücker,Nadeem Murtaza,Zsuzsa Lindenmaier,Jacob Ellegood,Anne Naumann,Bing Zhao,Birgit Schwanke,Jan Sedlacik,Jens Fiehler,Ileana L. Hanganu-Opatz,Jason P. Lerch,Karun K. Singh,Froylan Calderon de Anda +16 more
TL;DR: In this article , the authors show that Taok2, encoded in humans within the autism spectrum disorder (ASD) susceptibility locus 16p11.2, is essential for neuronal migration and that de novo mutations or rare variants from ASD patients disrupts neuronal migration in an iso-form-specific manner.