T. Watanabe
University of Nebraska Medical Center
7 Papers
216 Citations
T. Watanabe is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Progenitor cell & Bone marrow. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Gene Transfer Into Human Bone Marrow Hematopoietic Cells Mediated by Adenovirus Vectors
T. Watanabe,Charles A. Kuszynski,Kazuhiko Ino,Dean G. Heimann,HM Shepard,Y Yasui,DC Maneval,James E. Talmadge +7 more
TL;DR: Data indicate that recombinant adenovirus vectors can be used to transfer genes to human BM hematopoietic cells with expression of the exogenous gene at a high transduction efficiency.
78
GM-CSF-mobilized peripheral blood CD34 + cells differ from steady- state bone marrow CD34 + cells in adhesion molecule expression
TL;DR: It is suggested that PC mobilization occurs as a stochastic process and is associated with the selection of CD34+ cells with low adhesion molecule expression.
76
•Journal Article
Cell adhesion molecule expression on CD34+ cells in grafts and time to myeloid and platelet recovery after autologous stem cell transplantation.
T. Watanabe,Bhavana J. Dave,Dean G. Heimann,John D. Jackson,Anne Kessinger,James E. Talmadge +5 more
TL;DR: L-selectin or CD44 may play an important role in the homing of progenitors after autologous stem cell transplantation and may provide one explanation for the more rapid hematologic reconstitution observed after PBSC transplantation.
68
•Journal Article
In vivo protective effects of tetrapeptide AcSDKP, with or without granulocyte colony-stimulation factor, on murine progenitor cells after sublethal irradiation.
T. Watanabe,Gregory S. Brown,Linda S. Kelsey,Yun Yan,John D. Jackson,C. Ewel,Anne Kessinger,James E. Talmadge +7 more
TL;DR: It is concluded that ACSDKP has a radioprotective effect in vivo for progenitor cells, and that time of initiation and duration of Ac SDKP administration relative to irradiation are crucial for these effects.
29
Enhancement of adenovirus-mediated gene transfer to human bone marrow cells
T. Watanabe,Linda S. Kelsey,Ana G. Ageitos,Charles A. Kuszynski,Kazuhiko Ino,Dean G. Heimann,Michelle T. Varney,H. Michael Shepard,Mei Vaillancourt,Daniel C. Maneval,James E. Talmadge +10 more
TL;DR: It is concluded that a 24 hour exposure to recombinant adenovirus encoding p53 or beta-gal, at a MOI of 50-100 is optimal for in vitro gene transfer to BM cells and has no significant effect on hematopoietic function.
15