T. Olender
Weizmann Institute of Science
7 Papers
37 Citations
T. Olender is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Gene & Chromosomal region. The author has an hindex of 5, co-authored 7 publications.
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Papers
Mucolipidosis type IV: Novel MCOLN1 mutations in Jewish and non‐Jewish patients and the frequency of the disease in the Ashkenazi Jewish population
Ruth Bargal,Nili Avidan,T. Olender,Edna Ben Asher,Marcia Zeigler,Annick Raas-Rothschild,Ayala Frumkin,Omer Ben-Yoseph,Yechiel Friedlender,Doron Lancet,Gideon Bach +10 more
TL;DR: A preferred nucleotide numbering system for MCOLN1 mutations is presented and the issue of a screening program for the detection of high‐risk families in the Jewish Ashkenazi population is discussed.
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A role for TENM1 mutations in congenital general anosmia
Anna Alkelai,T. Olender,Rebecca Haffner-Krausz,Michael Tsoory,V. Boyko,Pavlo Tatarskyy,Ruth Gross-Isseroff,Roni Milgrom,Sagit Shushan,Sagit Shushan,I. Blau,E. Cohn,R. Beeri,E. Levy-Lahad,Elon Pras,Elon Pras,Doron Lancet +16 more
TL;DR: Results of the study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction, however, additional studies should be done in larger CGA cohorts, to provide statistical evidence that loss‐of‐function mutations in TENm1 can solely cause the disease in the authors' and other CGA cases.
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Exome sequencing as a differential diagnosis tool: resolving mild trichohepatoenteric syndrome.
Danit Oz-Levi,Batia Weiss,Batia Weiss,Avishay Lahad,Shoshana Greenberger,B. Pode-Shakked,Raz Somech,Raz Somech,T. Olender,P Tatarsky,D. Marek-Yagel,Elon Pras,Yair Anikster,Yair Anikster,Doron Lancet +14 more
TL;DR: The genetic resolution of a mild case of congenital diarrhea by whole-exome sequencing is reported, with implications to the utility of routine use of such analysis as a routine clinical diagnostics tool.
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Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Ronit I. Yarden,Ronit I. Yarden,Ronit I. Yarden,Eitan Friedman,Sally Metsuyanim,T. Olender,Edna Ben-Asher,Moshe Z. Papa +7 more
TL;DR: It is suggested that genes that act upstream of p53, or participate in the DNA damage response, may modify the risk of cancer in women with mutant BRCA1/2 alleles.
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Evidence for an interaction of schizophrenia susceptibility loci on chromosome 6q23.3 and 10q24.33–q26.13 in Arab Israeli families
Anna Alkelai,Yoav Kohn,T. Olender,K. Sarner-Kanyas,Amihai Rigbi,Adnan Hamdan,Edna Ben-Asher,Doron Lancet,Bernard Lerer +8 more
TL;DR: To test the hypothesis of genetic interaction between these two loci and to identify the type of interaction between them, two‐locus multipoint linkage analysis under three complex disease inheritance models (heterogeneity, multiplicative, and additive models) yielded a best maximum LOD score under the multiplicative model.
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