T. M. Siler
University of California, San Diego
9 Papers
361 Citations
T. M. Siler is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Somatostatin & Prolactin. The author has an hindex of 9, co-authored 9 publications.
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Papers
Modulation of pituitary responsiveness to LRF by estrogen.
TL;DR: This finding indicates a direct inhibitory action of estradiol on the pituitary gonadotrophs' sensitivity to LRF which may represent an important component of the negative feedback system on gonadotropin release.
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Inhibition of the sleep-related peak in physiologic human growth hormone release by somatostatin.
TL;DR: The synthetic linear tetradecapeptide, somatostatin (125-250 μg bolus followed by constant infusion of 9-10 μg/min) was given over the first 90 min of sleep on 2 nights to each of 4 normal young men and on one night to an acromegalic patient as discussed by the authors.
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Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF.
TL;DR: Female subjects exhibited greater responses to both stimuli than male subjects, and TRF induced a more prompt and quantitatively greater PRL release which was unaccompanied by GH rise.
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Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects.
TL;DR: It is demonstrated that synthetic somatostatin (SRIF) induces a suppressive effect on circulating insulin and glucose levels in normal human subjects.
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Augmented gonadotropin response to synthetic LRF in hypogonadal state.
T. M. Siler,Samuel S. C. Yen +1 more
TL;DR: In women with hypogonadal function, synthetic LRF elicited a prompt and sustained increase in circulating LH and FSH concentrations, indicating that in the absence of gonadal steroid feedback the sensitivity of pituitary gonadotrophs to LRF is enhanced which may relfect an increased pituitsary storage of readily releasable LH andFSH in hypog onadal subjects.
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