Sway P. Chen
Columbia University Medical Center
9 Papers
2 Citations
Sway P. Chen is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Recombinase & DNA repair. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Sway P. Chen include Harvard University & Columbia University.
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Papers
Proton Pump Inhibitors Alter Specific Taxa in the Human Gastrointestinal Microbiome: A Crossover Trial
Daniel E. Freedberg,Nora C. Toussaint,Sway P. Chen,Adam J. Ratner,Susan Whittier,Timothy C. Wang,Harris H. Wang,Julian A. Abrams +7 more
TL;DR: In a functional analysis, there were no changes in bile acids on PPIs, but there was an increase in genes involved in bacterial invasion that could provide a mechanism by which PPIs predispose to CDI.
284
Manipulating Bacterial Communities by in situ Microbiome Engineering.
TL;DR: It is argued that 'in situ microbiome engineering' represents a new paradigm of community-scale genetic and microbial engineering that can directly add, remove, or modify specific sets of functions and alter community-level properties in terrestrial, aquatic, and host-associated microbial communities.
252
Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
Christopher Fang-Yen,Matthieu Wyart,Matthieu Wyart,Julie Xie,Risa Kawai,Thomas E. Kodger,Sway P. Chen,Quan Wen,Quan Wen,Aravinthan D. T. Samuel +9 more
TL;DR: This work studies the undulatory movements of C. elegans in Newtonian fluids spanning nearly five orders of magnitude in viscosity and suggests that the nematode locomotory gait continuously adapts to external mechanical load in order to maintain propulsive thrust.
Metagenomic engineering of the mammalian gut microbiome in situ
TL;DR: MAGIC introduces conjugative plasmids into complex microbial communities in situ, enabling genetic modifications in gut microbiota, and demonstrates that diverse taxa in the mouse gut microbiome can be modified directly with a desired genetic payload.
207
An Engineered Cas-Transposon System for Programmable and Precise DNA Transpositions
Sway P. Chen,Harris H. Wang +1 more
TL;DR: A Cas-Transposon (CasTn) system for genomic insertions that uses a transposase fused to a catalytically-dead dCas9 nuclease to mediate programmable, site-specific transposition to expand the genomic engineering toolbox.