Swatee Dey
Procter & Gamble
24 Papers
421 Citations
Swatee Dey is an academic researcher from Procter & Gamble. The author has contributed to research in topics: Apoptosis & Medicine. The author has an hindex of 16, co-authored 22 publications. Previous affiliations of Swatee Dey include University of Kentucky.
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Papers
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
Swatee Dey,Vasudevan Bakthavatchalu,Michael T. Tseng,Peng Wu,Rebecca L. Florence,Eric A. Grulke,Robert A. Yokel,Sanjit K. Dhar,Hsin-Sheng Yang,Yumin Chen,Daret K. St. Clair +10 more
TL;DR: The results identify SIRT1 as an AP-1 modulator and suggest a novel mechanism by which alumina nanoparticles may function as a potential carcinogen.
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The Impact of TNF-α Induction on Therapeutic Efficacy following High Dose Spatially Fractionated (GRID) Radiation
Sabapathi Sathishkumar,Swatee Dey,Ali S. Meigooni,William F. Regine,Mahesh S Kudrimoti,Mansoor M. Ahmed,Mohammed Mohiuddin +6 more
TL;DR: High dose spatially fractionated (GRID) radiation results in significant induction of TNF-α that can be measured in serum of some patients 24 – 72 hours after radiation.
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Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3.
TL;DR: Par-4 is functionally required to cause radiation-induced apoptosis by abrogating the survival and anti-apoptotic effects of NFκB activity and bcl-2 function respectively.
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Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.
Anindita Das,Damodaran Chendil,Swatee Dey,Maleeha Mohiuddin,Mohammed Mohiuddin,Jeffrey Milbrandt,Vivek M. Rangnekar,Mansoor M. Ahmed +7 more
TL;DR: The results indicate that Egr-1 may transregulate p53, and both EGR-1 and p53 functions are essential to mediate radiation-induced apoptosis, which may involve the mediation of Rb protein that is essential to overcome the antiapoptotic function of MDM2 on p53.
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Restoration of Transforming Growth Factor-β Signaling Enhances Radiosensitivity by Altering the Bcl-2/Bax Ratio in the p53 Mutant Pancreatic Cancer Cell Line MIA PaCa-2
Mansoor M. Ahmed,Rachael A. Alcock,Damodaran Chendil,Swatee Dey,Anindita Das,Kolaparthi Venkatasubbarao,Mohammed Mohiuddin,Lu-Zhe Sun,William E. Strodel,James W. Freeman +9 more
TL;DR: Restoration of TGF-β signaling sensitized these cells to ionizing radiation, although these cells possess a mutated p53 gene, implying that RII is an important component of radiation-induced RII signaling, and loss of function of RII may enhance resistance to radiation- induced apoptosis.
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