Abstract BACKGROUND AND AIMS Haemodiafiltration on-line (HDF-ol), an effective mode of replacement therapy for stage 5 chronic kidney disease (CKD 5D), cannot be considered sufficiently studied in terms of its effect on the outcomes. Our main aim was to identify a possible association between individual anthropometric, laboratory data and parameters of the prescribed treatment regimen with the best survival rate when using the HDF-ol mode. METHOD A retrospective1 year analysis of the EuCliD database of 9986 patients treated with HDF-ol in 27 Fresenius Medical Care centres in Russia was carried out. All patients got post-dilution HDF-ol procedures at least 3 times a week, for at least 12 h a week with Kt/V at least 1.4. Data on alive (9616) and deceased (370) patients were compared by gender, age, treatment experience, body weight (BW), body mass index (BMI), body surface area (BSA), total body water volume (TBW), volume of urea distribution (V Urea BCM), presence of diabetes mellitus (DM), ischemic heart disease (CHD), chronic heart failure (CHF), as well as parameters of the procedure: effective weekly dialysis time, Kt/V, effective infusion volume (EIV) and effective convection volume (ECV). RESULTS Differences in groups were found only for a part of parameters (Table 1).Table 1. Group of patients Statistic Alive Deceased P-value Basic demographic characteristics Sex: f n (%) 4422 (46.0%) 140 (37.8%) .0024 Sex: m n (%) 5194 (54.0%) 230 (62.2%) .0024 Age (years) N 9616 370 <.0001 Mean (SD) 53.4 (13.6) 58.8 (12.1) Median 55 60 Min–max 17.0–86.0 30.0–83.0 95% CI 53.1–53.7 57.5–60.0 BW (kg) N 9616 370 <.0001 Mean (SD) 75.2 (17.5) 71.7 (16.5) Median 73.4 70 Min–max 30.6–194.6 35.3–133.2 95% CI 74.8–75.5 70.0–73.4 BMI Mean (SD) 26.7 (5.7) 25.5 (5.7) <.0001 Median 26 25 Min–max 14.1–53.2 13.4–47.2 95% CI 26.6–26.9 24.9–26.1 CHD: yes n (%) 1565 (16.3%) 98 (26.5%) <.0001 CHD: no n (%) 8051 (83.7%) 272 (73.5%) <.0001 HF: yes n (%) 1878 (19.5%) 94 (25.4%) .0065 HF: no n (%) 7738 (80.5%) 276 (74.6%) .0065 diabetes: yes n (%) 1213 (12.6%) 72 (19.5%) .0002 diabetes: no n (%) 8403 (87.4%) 298 (80.5%) .0002 Parameters of the HDF ol procedures Effective week dialysis time (min) Mean (SD) 784.2 (140.2) 731.6 (372.2) <.0001 Median 790 733,5 Min–max 150.0–4979.0 197.0–4017.0 95% CI 781.3–787.1 689.6–773.6 EIV (L) Mean (SD) 24.6 (4.3) 23.0 (4.7) <.0001 Median 23.7 22.4 Min–max 0.5–69.4 1.9–43.8 95% CI 24.5–24.7 22.6–23.5 ECV (L) Mean (SD) 27.0 (4.4) 25.3 (5.0) <.0001 Median 26 24.7 Min–max 0.5–71.2 2.0–46.0 95% CI 26.9–27.1 24.8–25.8 OCM Kt/V Mean (SD) 1.7 (0.3) 1.7 (0.3) <.0001 Median 1.7 1.6 Min–max 0.5–6.4 0.7–3.0 95% CI 1.7–1.7 1.7–1.7 The main laboratory parameters Calcium (mmol/L) Mean (SD) 2.2 (0.2) 2.3 (0.2) <.0001 Median 2.2 2.2 Min–max 1.0–3.7 1.5–3.0 95% CI 2.2–2.2 2.2–2.3 Albumin (g/L) Mean (SD) 40.6 (3.2) 38.7 (4.3) <.0001 Median 41 39 Min–max 13.0–71.0 18.2–49.0 95% CI 40.5–40.6 38.4–38.9 b2-microglobulin (mg/L) Mean (SD) 23.8 (7.0) 25.2 (8.1) <.0001 Median 23.3 23.7 Min–max 1.5–80.0 5.4–85.1 95% CI 23.8–23.9 24.7–25.7 Haemoglobin (g/L) Mean (SD) 110.4 (14.9) 105.6 (17.9) <.0001 Median 111 106 Min–max 12.0–176.0 34.0–167.0 95% CI 110.2–110.5 104.5-106.7 CRP (mg/L) Mean (SD) 7.8 (15.7) 19.7 (43.3) <.0001 Median 3.4 6.6 Min–max 0.0–500.0 0.1–521.1 95% CI 7.6–7.9 17.0–22.4 Table 2. Hospitalization of ESKD patients before and after the onset of the COVID-19 pandemic in a tertiary University Hospital of Thessaloniki, Greece Before COVID-19 pandemic After COVID-19 pandemic P-value Time period 1 March 2019–29 February 2021 1 March 2020–28 February 2021 - Hospitalizationsa (n) 149 90 - Age (years) 67.7 ± 13.6 65.3 ± 16.7 247 Gender (M/F) 105/44 (70.5%/29.5%) 62/28 (68.9%/31.1%) 884 Duration of hospitalization (days) 7 (2–83) 9 (2–67) 0.423 Outcome (n, %) 0.837  Improvement 127 (85.2%) 76 (84.4%)  Stable medical condition 10 (6.7%) 6 (6.7%)  In-hospital death 12 (8.1%) 8 (8.9%) aHospitalizations due to SARS-CoV-2 infection over the pandemic period were not included in this comparative analysis. CONCLUSION Association of risk of death in patients with CKD 5D treated with HDF-ol included male gender, older age, concomitant diseases (CHD, CHF, DM), lower BW and BMI, shorter effective weekly dialysis time, lower values of EIV and ECV, Kt/V, higher values of hypercalcemia, hypoalbuminemia, lower haemoglobin levels, higher levels of b2-microglobulin and CRP. Such indicators as TBW, VUrea BCM, BSA and the length of treatment on dialysis did not reached statistical significance when comparing alivе and deceased patients.

https://academic.oup.com/ndt/article-pdf/37/Supplement_3/gfac084.002/43535700/gfac084_002.pdf

MO907: Predictors of Negative Outcomes in HDF-OL Patients: A Cohort Study

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MO907: Predictors of Negative Outcomes in HDF-OL Patients: A Cohort Study