Suzanne Manning
University of Queensland
12 Papers
96 Citations
Suzanne Manning is an academic researcher from University of Queensland. The author has contributed to research in topics: Biology & DNA methylation. The author has an hindex of 11, co-authored 12 publications.
Chat about Author
Papers
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
3.2K
Whole genomes redefine the mutational landscape of pancreatic cancer.
Nicola Waddell,Marina Pajic,Ann-Marie Patch,David K. Chang,Karin S. Kassahn,Peter Bailey,Amber L. Johns,David Miller,Katia Nones,Kelly Quek,Michael C.J. Quinn,Alan J. Robertson,Muhammad Zaki Hidayatullah Fadlullah,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Ehsan Nourbakhsh,Shivangi Wani,Peter J. Wilson,Emma Markham,Nicole Cloonan,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Stephen H. Kazakoff,Conrad Leonard,Felicity Newell,Barsha Poudel,Sarah Song,Darrin Taylor,Nick Waddell,Scott Wood,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Hong C. Lee,Marc D. Jones,Adnan Nagrial,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Angela Steinmann,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,Jessica A. Pettitt,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Janet Graham,Simone P. Niclou,Rolf Bjerkvig,Robert Grützmann,Daniela Aust,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Massimo Falconi,Giuseppe Zamboni,Giampaolo Tortora,Margaret A. Tempero,Anthony J. Gill,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond +88 more
TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.
2.5K
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin,Andrew V. Biankin,Andrew V. Biankin,Nicola Waddell,Karin S. Kassahn,Marie-Claude Gingras,Lakshmi Muthuswamy,Amber L. Johns,David Miller,Peter Wilson,Ann-Marie Patch,Jianmin Wu,David K. Chang,David K. Chang,David K. Chang,Mark J. Cowley,Brooke Gardiner,Sarah Song,Ivon Harliwong,Senel Idrisoglu,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Shivangi Wani,Milena Gongora,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Anthony J. Gill,Anthony J. Gill,Anthony J. Gill,Andreia V. Pinho,Ilse Rooman,Matthew J. Anderson,Oliver Holmes,Conrad Leonard,Darrin Taylor,Scott Wood,Qinying Xu,Katia Nones,J. Lynn Fink,Angelika N. Christ,Timothy J. C. Bruxner,Nicole Cloonan,Gabriel Kolle,Felicity Newell,Mark Pinese,R. Scott Mead,R. Scott Mead,Jeremy L. Humphris,Warren Kaplan,Marc D. Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Angela Chou,Angela Chou,Venessa T. Chin,Lorraine A. Chantrill,Amanda Mawson,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Roger J. Daly,Neil D. Merrett,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nipun Kakkar,Fengmei Zhao,Yuan Qing Wu,Min Wang,Donna M. Muzny,William E. Fisher,F. Charles Brunicardi,Sally E. Hodges,Jeffrey G. Reid,Jennifer Drummond,Kyle Chang,Yi Han,Lora Lewis,Huyen Dinh,Christian J. Buhay,Timothy Beck,Lee Timms,Michelle Sam,Kimberly Begley,Andrew M.K. Brown,Deepa Pai,Ami Panchal,Nicholas Buchner,Richard de Borja,Robert E. Denroche,Christina K. Yung,Stefano Serra,Nicole Onetto,Debabrata Mukhopadhyay,Ming-Sound Tsao,Patricia Shaw,Gloria M. Petersen,Steven Gallinger,Steven Gallinger,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Richard D. Schulick,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Paola Capelli,Vincenzo Corbo,Maria Scardoni,Giampaolo Tortora,Margaret A. Tempero,Karen M. Mann,Nancy A. Jenkins,Pedro A. Perez-Mancera,David J. Adams,David A. Largaespada,Lodewyk F. A. Wessels,Alistair G. Rust,Lincoln Stein,David A. Tuveson,Neal G. Copeland,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Aldo Scarpa,James R. Eshleman,Thomas J. Hudson,Robert L. Sutherland,Robert L. Sutherland,David A. Wheeler,John V. Pearson,John Douglas Mcpherson,Richard A. Gibbs,Sean M. Grimmond +140 more
TL;DR: It is found that frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, are also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement ofAxon guidance genes in pancreatic carcinogenesis.
2.1K
Whole-genome characterization of chemoresistant ovarian cancer
Ann-Marie Patch,Ann-Marie Patch,Elizabeth L. Christie,Dariush Etemadmoghadam,Dariush Etemadmoghadam,Dale W. Garsed,Joshy George,Sian Fereday,Katia Nones,Katia Nones,Prue A. Cowin,Kathryn Alsop,Peter Bailey,Peter Bailey,Karin S. Kassahn,Karin S. Kassahn,Felicity Newell,Michael C.J. Quinn,Michael C.J. Quinn,Stephen H. Kazakoff,Stephen H. Kazakoff,Kelly Quek,Charlotte Wilhelm-Benartzi,Edward Curry,Huei San Leong,Anne Hamilton,Anne Hamilton,Anne Hamilton,Linda Mileshkin,George Au-Yeung,Catherine Kennedy,Jillian Hung,Yoke Eng Chiew,Paul R. Harnett,Michael Friedlander,Michael C. J. Quinn,Jan Pyman,Stephen Cordner,Patricia C. M. O’Brien,Jodie Leditschke,Greg Young,Kate Strachan,Paul Waring,Walid J Azar,Chris Mitchell,Nadia Traficante,Joy Hendley,Heather Thorne,Mark Shackleton,David Miller,Gisela Mir Arnau,Richard W. Tothill,Timothy P. Holloway,Timothy Semple,Ivon Harliwong,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Senel Idrisoglu,Timothy J. C. Bruxner,Angelika N. Christ,Barsha Poudel,Oliver Holmes,Oliver Holmes,Matthew J. Anderson,Conrad Leonard,Conrad Leonard,Andrew Lonie,Nathan E. Hall,Scott Wood,Scott Wood,Darrin Taylor,Qinying Xu,Qinying Xu,J. Lynn Fink,Nick Waddell,Ronny Drapkin,Euan A. Stronach,Hani Gabra,Robert S. Brown,A. Jewell,Shivashankar H. Nagaraj,Emma Markham,Peter Wilson,Jason Ellul,Orla McNally,Maria A. Doyle,Ravikiran Vedururu,Collin Stewart,Ernst Lengyel,John V. Pearson,John V. Pearson,Nicola Waddell,Nicola Waddell,Anna deFazio,Sean M. Grimmond,Sean M. Grimmond,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell +99 more
TL;DR: It is shown that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance.
1.5K
Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling
Katia Nones,Nic Waddell,Sarah Song,Ann-Marie Patch,David Miller,Amber L. Johns,Jianmin Wu,Karin S. Kassahn,David L. A. Wood,Peter Bailey,Lynn Fink,Suzanne Manning,Angelika N. Christ,Craig Nourse,Stephen H. Kazakoff,Darrin Taylor,Conrad Leonard,David K. Chang,Marc D. Jones,Michelle Thomas,Clare Watson,Mark Pinese,Mark J. Cowley,Ilse Rooman,Marina Pajic,Giovanni Butturini,Anna Malpaga,Vincenzo Corbo,Stefano Crippa,Massimo Falconi,Giuseppe Zamboni,Paola Castelli,Rita T. Lawlor,Anthony J. Gill,Anthony J. Gill,Aldo Scarpa,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond +39 more
TL;DR: The methylation profiles of 167 untreated resected PDACs and a panel of 29 adjacent nontransformed pancreata using high‐density arrays suggest that aberrant methylation plays an important role in pancreatic carcinogenesis affecting core signaling pathways with potential implications for the disease pathophysiology and therapy.