Suzanne E. Berry
Case Western Reserve University
8 Papers
203 Citations
Suzanne E. Berry is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Thymidine & Cell cycle. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Suzanne E. Berry include University Hospitals of Cleveland.
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Papers
•Journal Article
DNA Mismatch Repair (MMR) Mediates 6-Thioguanine Genotoxicity by Introducing Single-strand Breaks to Signal a G2-M Arrest in MMR-proficient RKO Cells
TL;DR: The data suggest that MMR mediates 6-TG-induced G(2)-M arrest by introducing SSBs to signal a persistent G( 2-M arrest leading to enhanced cell death.
•Journal Article
Loss of DNA Mismatch Repair Imparts Defective cdc2 Signaling and G2 Arrest Responses without Altering Survival after Ionizing Radiation
Tao Yan,Jane E. Schupp,Hwa-Shin Hwang,Mark W. Wagner,Suzanne E. Berry,S. Strickfaden,Martina L. Veigl,W. D. Sedwick,David A. Boothman,Timothy J. Kinsella +9 more
TL;DR: Although MMR status does not significantly affect the survival of cells after high-dose-rate IR, it seems to regulate the G(2)-M checkpoint and might affect overall mutation rates.
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•Journal Article
Selective Radiosensitization of Drug-resistant MutS Homologue-2 (MSH2) Mismatch Repair-deficient Cells by Halogenated Thymidine (dThd) Analogues: Msh2 Mediates dThd Analogue DNA Levels and the Differential Cytotoxicity and Cell Cycle Effects of the dThd Analogues and 6-Thioguanine
Suzanne E. Berry,Thomas W. Davis,Jane E. Schupp,Hwa-Shin Hwang,Niels de Wind,Timothy J. Kinsella +5 more
TL;DR: IUrd and BrdUrd may be used clinically to selectively target both MLH1- and MSH2-deficient, drug-resistant cells for radiosensitization and the differential cytotoxicity and cell cycle effects of the halogenated dThd analogues compared with 6-TG.
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•Journal Article
The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells.
Suzanne E. Berry,Christopher Garces,Hwa Shin Hwang,Keith A. Kunugi,Mark Meyers,Thomas W. Davis,David A. Boothman,Timothy J. Kinsella +7 more
TL;DR: Whereas MMR-deficient cells and tumor xenografts have shown intrinsic resistance to a large number of chemotherapeutic agents, the 5-halogenated dThd analogues appear to selectively target cells that have lost the ability to perform MMR for potential enhanced radiation sensitivity.
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•Journal Article
Preclinical Study of the Systemic Toxicity and Pharmacokinetics of 5-Iodo-2-deoxypyrimidinone-2′-deoxyribose as a Radiosensitizing Prodrug in Two, Non-Rodent Animal Species: Implications for Phase I Study Design
Timothy J. Kinsella,Jane E. Schupp,Thomas W. Davis,Suzanne E. Berry,Hwa-Shin Hwang,Kathy Warren,Frank M. Balis,John Barnett,Howard Sands +8 more
TL;DR: It is concluded that there are dose-dependent microscopic changes in liver consisting of minimal to moderate cytoplasmic vacuolation of hepatocytes, which either occurred in the periportal area (high dosage group) or diffusely throughout the liver (lower dosage groups).
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