Suzanne Butt
3 Papers
115 Citations
Suzanne Butt is an academic researcher. The author has contributed to research in topics: Furanose & Guanosine. The author has an hindex of 3, co-authored 3 publications.
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Papers
Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent
Alan D. Borthwick,Suzanne Butt,Keith Biggadike,Anne M. Exall,Stanley M. Roberts,Peter Youds,Barrie E. Kirk,Brian R. Booth,Janet M. Cameron,Susan W. Cox,Clara L.P. Marr,Mark D. Shill +11 more
TL;DR: Carbocyclic-9-(2′-deoxy-2′ −β-fluoroarabinofuranosyl) guanine (8) and the corresponding furanose compound (12) have been synthesized; the former compound [which was resolved by formation of the monophosphate (20) and enantioselective hydrolysis using a 5′-nucleotidase] is an extremely potent inhibitor of herpes simplex viruses types 1 and 2.
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Reduction of bicyclo[3.2.0] hept-2-en-6-one and 7,7-dimethylbicyclo[3.2.0]hept-2-en-6-one using dehydrogenase enzymes and the fungus mortierella ramanniana
Suzanne Butt,H. Geoff Davies,Michael J. Dawson,Lawrence Gordon C,Jeff Leaver,Stanley M. Roberts,Michael K. Turner,Basil J. Wakefield,Wilfred F. Wall,John A. Winders +9 more
TL;DR: In this article, an alcohol dehydrogenase from Thermoanaerobium brockii and a whole cell system (M. ramanniana) with excellent substrate enantioselectivity was used to reduce 7,7-dimethylbicyclo.
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Resolution of 7,7-dimethylbicyclo[3.2.0]hept-2-en-6-one using Mortierella ramanniana and 3α,20β-hydroxy-steroid dehydrogenase, photochemistry of 3-hydroxy-7,7-dimethylbicyclo[3.2.0]heptan-6-ones, and the synthesis of (+)-eldanolide
Suzanne Butt,H. Geoff Davies,Michael J. Dawson,Lawrence Gordon C,Jeff Leaver,Stanley M. Roberts,Michael K. Turner,Basil J. Wakefield,Wilfred F. Wall,John A. Winders +9 more
TL;DR: The fungus Mortierella ramanniana reduced 7,7-dimethylbicyclo[3.2.0]hept-2-en-6-one (1) to give the (6S)-endo-alcohol (9) and the 6S)-exo-alcohol(10) in high optical purity as mentioned in this paper.
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